Role of transvenous implantable cardioverter-defibrillators in preventing sudden cardiac death in children, adolescents, and young adults

Ritu Chatrath, Co Burn J Porter, Michael John Ackerman

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Objective: To evaluate the indications, underlying cardiac disorders, efficacy, and complications involved with transvenous implantable cardioverter-defibrillators (ICDs) in pediatric patients at the Mayo Clinic. Patients and Methods: The records of all patients aged 21 years or younger who underwent transvenous ICD placement at the Mayo Clinic, Rochester, Minn, were reviewed retrospectively. Results: Between March 1992 and September 2000, 16 patients (7 females; mean age, 15.4 years; range, 10-21 years) underwent transvenous ICD placement. The ICD was implanted for primary prevention of sudden cardiac death in 7 and for secondary prevention in 9. The underlying cardiac disorders included hypertrophic cardiomyopathy in 6 patients and congenital long QT syndrome in 6 patients. The mean ± SD follow-up was 36±29 months (range, 5-108 months). There was no mortality. Seven patients (44%) received appropriate ICD therapy, including 6 of 9 who had ICDs placed for secondary prevention. Median time free from appropriate ICD discharge was 3 years (range, 0.2-9 years). Three patients (19%) experienced inappropriate ICD discharge. Two patients needed device replacement because of technical problems (lead fracture and device malfunction). Two patients developed pocket infection that required removal and reimplantation of the ICD. Conclusion: In adolescents and young adults, transvenous ICDs may prevent sudden death but are not free of complications. Forty-four percent of this cohort received potentially life-saving ICD therapy, including two thirds who received an ICD for secondary prevention.

Original languageEnglish (US)
Pages (from-to)226-231
Number of pages6
JournalMayo Clinic Proceedings
Volume77
Issue number3
StatePublished - 2002

Fingerprint

Implantable Defibrillators
Sudden Cardiac Death
Young Adult
Secondary Prevention
Long QT Syndrome
Equipment and Supplies
Replantation
Hypertrophic Cardiomyopathy
Primary Prevention
Sudden Death

Keywords

  • ARVD = arrhythmogenic right ventricular dysplasia
  • DFT = defibrillation threshold
  • HCM = hypertrophic cardiomyopathy
  • ICD = implantable cardioverter-defibrillator
  • LQTS = long QT syndrome
  • OHCA = out-of-hospital cardiac arrest
  • QTc = corrected QT interval
  • VF = ventricular fibrillation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Role of transvenous implantable cardioverter-defibrillators in preventing sudden cardiac death in children, adolescents, and young adults. / Chatrath, Ritu; Porter, Co Burn J; Ackerman, Michael John.

In: Mayo Clinic Proceedings, Vol. 77, No. 3, 2002, p. 226-231.

Research output: Contribution to journalArticle

@article{bb6d5220d88645088a473b30620d4222,
title = "Role of transvenous implantable cardioverter-defibrillators in preventing sudden cardiac death in children, adolescents, and young adults",
abstract = "Objective: To evaluate the indications, underlying cardiac disorders, efficacy, and complications involved with transvenous implantable cardioverter-defibrillators (ICDs) in pediatric patients at the Mayo Clinic. Patients and Methods: The records of all patients aged 21 years or younger who underwent transvenous ICD placement at the Mayo Clinic, Rochester, Minn, were reviewed retrospectively. Results: Between March 1992 and September 2000, 16 patients (7 females; mean age, 15.4 years; range, 10-21 years) underwent transvenous ICD placement. The ICD was implanted for primary prevention of sudden cardiac death in 7 and for secondary prevention in 9. The underlying cardiac disorders included hypertrophic cardiomyopathy in 6 patients and congenital long QT syndrome in 6 patients. The mean ± SD follow-up was 36±29 months (range, 5-108 months). There was no mortality. Seven patients (44{\%}) received appropriate ICD therapy, including 6 of 9 who had ICDs placed for secondary prevention. Median time free from appropriate ICD discharge was 3 years (range, 0.2-9 years). Three patients (19{\%}) experienced inappropriate ICD discharge. Two patients needed device replacement because of technical problems (lead fracture and device malfunction). Two patients developed pocket infection that required removal and reimplantation of the ICD. Conclusion: In adolescents and young adults, transvenous ICDs may prevent sudden death but are not free of complications. Forty-four percent of this cohort received potentially life-saving ICD therapy, including two thirds who received an ICD for secondary prevention.",
keywords = "ARVD = arrhythmogenic right ventricular dysplasia, DFT = defibrillation threshold, HCM = hypertrophic cardiomyopathy, ICD = implantable cardioverter-defibrillator, LQTS = long QT syndrome, OHCA = out-of-hospital cardiac arrest, QTc = corrected QT interval, VF = ventricular fibrillation",
author = "Ritu Chatrath and Porter, {Co Burn J} and Ackerman, {Michael John}",
year = "2002",
language = "English (US)",
volume = "77",
pages = "226--231",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "3",

}

TY - JOUR

T1 - Role of transvenous implantable cardioverter-defibrillators in preventing sudden cardiac death in children, adolescents, and young adults

AU - Chatrath, Ritu

AU - Porter, Co Burn J

AU - Ackerman, Michael John

PY - 2002

Y1 - 2002

N2 - Objective: To evaluate the indications, underlying cardiac disorders, efficacy, and complications involved with transvenous implantable cardioverter-defibrillators (ICDs) in pediatric patients at the Mayo Clinic. Patients and Methods: The records of all patients aged 21 years or younger who underwent transvenous ICD placement at the Mayo Clinic, Rochester, Minn, were reviewed retrospectively. Results: Between March 1992 and September 2000, 16 patients (7 females; mean age, 15.4 years; range, 10-21 years) underwent transvenous ICD placement. The ICD was implanted for primary prevention of sudden cardiac death in 7 and for secondary prevention in 9. The underlying cardiac disorders included hypertrophic cardiomyopathy in 6 patients and congenital long QT syndrome in 6 patients. The mean ± SD follow-up was 36±29 months (range, 5-108 months). There was no mortality. Seven patients (44%) received appropriate ICD therapy, including 6 of 9 who had ICDs placed for secondary prevention. Median time free from appropriate ICD discharge was 3 years (range, 0.2-9 years). Three patients (19%) experienced inappropriate ICD discharge. Two patients needed device replacement because of technical problems (lead fracture and device malfunction). Two patients developed pocket infection that required removal and reimplantation of the ICD. Conclusion: In adolescents and young adults, transvenous ICDs may prevent sudden death but are not free of complications. Forty-four percent of this cohort received potentially life-saving ICD therapy, including two thirds who received an ICD for secondary prevention.

AB - Objective: To evaluate the indications, underlying cardiac disorders, efficacy, and complications involved with transvenous implantable cardioverter-defibrillators (ICDs) in pediatric patients at the Mayo Clinic. Patients and Methods: The records of all patients aged 21 years or younger who underwent transvenous ICD placement at the Mayo Clinic, Rochester, Minn, were reviewed retrospectively. Results: Between March 1992 and September 2000, 16 patients (7 females; mean age, 15.4 years; range, 10-21 years) underwent transvenous ICD placement. The ICD was implanted for primary prevention of sudden cardiac death in 7 and for secondary prevention in 9. The underlying cardiac disorders included hypertrophic cardiomyopathy in 6 patients and congenital long QT syndrome in 6 patients. The mean ± SD follow-up was 36±29 months (range, 5-108 months). There was no mortality. Seven patients (44%) received appropriate ICD therapy, including 6 of 9 who had ICDs placed for secondary prevention. Median time free from appropriate ICD discharge was 3 years (range, 0.2-9 years). Three patients (19%) experienced inappropriate ICD discharge. Two patients needed device replacement because of technical problems (lead fracture and device malfunction). Two patients developed pocket infection that required removal and reimplantation of the ICD. Conclusion: In adolescents and young adults, transvenous ICDs may prevent sudden death but are not free of complications. Forty-four percent of this cohort received potentially life-saving ICD therapy, including two thirds who received an ICD for secondary prevention.

KW - ARVD = arrhythmogenic right ventricular dysplasia

KW - DFT = defibrillation threshold

KW - HCM = hypertrophic cardiomyopathy

KW - ICD = implantable cardioverter-defibrillator

KW - LQTS = long QT syndrome

KW - OHCA = out-of-hospital cardiac arrest

KW - QTc = corrected QT interval

KW - VF = ventricular fibrillation

UR - http://www.scopus.com/inward/record.url?scp=0036181111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036181111&partnerID=8YFLogxK

M3 - Article

C2 - 11888025

AN - SCOPUS:0036181111

VL - 77

SP - 226

EP - 231

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 3

ER -