Role of the tumor microenvironment in mature B-cell lymphoid malignancies

Nathan H. Fowler, Chan Yoon Cheah, Randy D. Gascoyne, John Gribben, Sattva S. Neelapu, Paolo Ghia, Catherine Bollard, Stephen Ansell, Michael Curran, Wyndham H. Wilson, Susan O’Brien, Cliona Grant, Richard Little, Thorsten Zenz, Loretta J. Nastoupil, Kieron Dunleavy

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

The tumor microenvironment is the cellular and molecular environment in which the tumor exists and with which it continuously interacts. In B-cell lymphomas, this microenvironment is intriguing in that it plays critical roles in the regulation of tumor cell survival and proliferation, fostering immune escape as well as the development of treatment resistance. The purpose of this review is to summarize the proceedings of the Second Annual Summit on the Immune Microenvironment in Hematologic Malignancies that took place on September 11-12, 2014 in Dublin, Ireland. We provide a timely overview of the composition and biological relevance of the cellular and molecular microenvironment interface and discuss the role of interactions between the microenvironment and neoplastic cells in a variety of B-cell lymphomas. In addition, we focus on various novel therapeutic strategies that target the tumor microenvironment, including agents that modulate B-cell receptor pathways and immune-checkpoints, chimeric antigen receptor T cells and immunomodulatory agents.

Original languageEnglish (US)
Pages (from-to)531-540
Number of pages10
JournalHaematologica
Volume101
Issue number5
DOIs
StatePublished - Apr 30 2016

ASJC Scopus subject areas

  • Hematology

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    Fowler, N. H., Cheah, C. Y., Gascoyne, R. D., Gribben, J., Neelapu, S. S., Ghia, P., Bollard, C., Ansell, S., Curran, M., Wilson, W. H., O’Brien, S., Grant, C., Little, R., Zenz, T., Nastoupil, L. J., & Dunleavy, K. (2016). Role of the tumor microenvironment in mature B-cell lymphoid malignancies. Haematologica, 101(5), 531-540. https://doi.org/10.3324/haematol.2015.139493