Role of the tumor microenvironment in mature B-cell lymphoid malignancies

Nathan H. Fowler, Chan Yoon Cheah, Randy D. Gascoyne, John Gribben, Sattva S. Neelapu, Paolo Ghia, Catherine Bollard, Stephen Maxted Ansell, Michael Curran, Wyndham H. Wilson, Susan O’Brien, Cliona Grant, Richard Little, Thorsten Zenz, Loretta J. Nastoupil, Kieron Dunleavy

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The tumor microenvironment is the cellular and molecular environment in which the tumor exists and with which it continuously interacts. In B-cell lymphomas, this microenvironment is intriguing in that it plays critical roles in the regulation of tumor cell survival and proliferation, fostering immune escape as well as the development of treatment resistance. The purpose of this review is to summarize the proceedings of the Second Annual Summit on the Immune Microenvironment in Hematologic Malignancies that took place on September 11-12, 2014 in Dublin, Ireland. We provide a timely overview of the composition and biological relevance of the cellular and molecular microenvironment interface and discuss the role of interactions between the microenvironment and neoplastic cells in a variety of B-cell lymphomas. In addition, we focus on various novel therapeutic strategies that target the tumor microenvironment, including agents that modulate B-cell receptor pathways and immune-checkpoints, chimeric antigen receptor T cells and immunomodulatory agents.

Original languageEnglish (US)
Pages (from-to)531-540
Number of pages10
JournalHaematologica
Volume101
Issue number5
DOIs
StatePublished - Apr 30 2016

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Cellular Microenvironment
Tumor Microenvironment
B-Lymphocytes
B-Cell Lymphoma
Neoplasms
Foster Home Care
Hematologic Neoplasms
T-Cell Antigen Receptor
Ireland
Cell Survival
Cell Proliferation
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Fowler, N. H., Cheah, C. Y., Gascoyne, R. D., Gribben, J., Neelapu, S. S., Ghia, P., ... Dunleavy, K. (2016). Role of the tumor microenvironment in mature B-cell lymphoid malignancies. Haematologica, 101(5), 531-540. https://doi.org/10.3324/haematol.2015.139493

Role of the tumor microenvironment in mature B-cell lymphoid malignancies. / Fowler, Nathan H.; Cheah, Chan Yoon; Gascoyne, Randy D.; Gribben, John; Neelapu, Sattva S.; Ghia, Paolo; Bollard, Catherine; Ansell, Stephen Maxted; Curran, Michael; Wilson, Wyndham H.; O’Brien, Susan; Grant, Cliona; Little, Richard; Zenz, Thorsten; Nastoupil, Loretta J.; Dunleavy, Kieron.

In: Haematologica, Vol. 101, No. 5, 30.04.2016, p. 531-540.

Research output: Contribution to journalArticle

Fowler, NH, Cheah, CY, Gascoyne, RD, Gribben, J, Neelapu, SS, Ghia, P, Bollard, C, Ansell, SM, Curran, M, Wilson, WH, O’Brien, S, Grant, C, Little, R, Zenz, T, Nastoupil, LJ & Dunleavy, K 2016, 'Role of the tumor microenvironment in mature B-cell lymphoid malignancies', Haematologica, vol. 101, no. 5, pp. 531-540. https://doi.org/10.3324/haematol.2015.139493
Fowler NH, Cheah CY, Gascoyne RD, Gribben J, Neelapu SS, Ghia P et al. Role of the tumor microenvironment in mature B-cell lymphoid malignancies. Haematologica. 2016 Apr 30;101(5):531-540. https://doi.org/10.3324/haematol.2015.139493
Fowler, Nathan H. ; Cheah, Chan Yoon ; Gascoyne, Randy D. ; Gribben, John ; Neelapu, Sattva S. ; Ghia, Paolo ; Bollard, Catherine ; Ansell, Stephen Maxted ; Curran, Michael ; Wilson, Wyndham H. ; O’Brien, Susan ; Grant, Cliona ; Little, Richard ; Zenz, Thorsten ; Nastoupil, Loretta J. ; Dunleavy, Kieron. / Role of the tumor microenvironment in mature B-cell lymphoid malignancies. In: Haematologica. 2016 ; Vol. 101, No. 5. pp. 531-540.
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