Role of the renal nerves in the development of renal cystic disease in Han

SPRD rats

A. A. Khraibi, R. Bengal, Vicente Torres

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The objective of this study was to determine whether decreased renal sympathetic nerve activity would have a protective effect on the development of renal cystic disease in male Han:SPRD rats. Unilateral denervation was performed on the left kidney at 3 and 6 weeks of age (n=8) and cy/deg; rats (n=5) were studied at 9 weeks of age Renal denervation resulted in lower tissue norepinephrine concentrations (422±21.3 vs 218.3±27.5 ng/g tissue; P<0.05), and lower renin scores (9.2±4 4 vs 19.6±8.2 positive arterioles/100 glomeruli, P<0.05), and better preservation of the cortical tubular cell volume in the denervated kidneys as compared to the contralateral innervated kidneys (1.17±0.20 vs 0.90±0 08 ml; P<0.05) of the same Han:SPRD rats. No significant differences in cortical luminal volume (0.93±0.19 vs 0.90±0.18 ml) or cortical interstitial volume (0.33±0.06 vs. 0.31±0.05 ml) were detected between the denervated kidneys and the innervated kidneys respectively In conclusion, these results indicate that chronic renal denervation has a beneficial effect on the development of polycystic kidney disease in male Han:SPRD rats and suggests that early treatment with specific adrenergic receptor antagonists has a potential for directly or indirectly affecting the development of autosomal dominant polycystic kidney disease in humans.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

Fingerprint

Cystic Kidney Diseases
Rats
nerve tissue
kidneys
Kidney
rats
Denervation
Tissue
Adrenergic Antagonists
Renin
Norepinephrine
Autosomal Dominant Polycystic Kidney
Polycystic Kidney Diseases
renin
Arterioles
Cell Size
adrenergic receptors
norepinephrine
protective effect
antagonists

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Role of the renal nerves in the development of renal cystic disease in Han : SPRD rats. / Khraibi, A. A.; Bengal, R.; Torres, Vicente.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

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