Role of the pancreas in the control of interdigestive gastrointestinal motility

Peter Malfertheiner; Michael G. Sarr; Eugene P. DiMagno

doi:10.1016/0016-5085(89)90781-6

Role of the pancreas in the control of interdigestive gastrointestinal motility

Peter Malfertheiner, Michael G. Sarr, Eugene P. DiMagno

Gastroenterologic and General Surgery

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Our aim was to determine if the pancreas regulates the interdigestive motor patterns of the upper gut. Four dogs were prepared with gastric and intestinal manometry catheters and interdigestive (fasting) motility was measured before and after total surgical pancreatectomy. The characteristics of the gastric and intestinal migrating motor complex were very similar before and after pancreatectomy. The time intervals between successive migrating motor complexes in the antrum (145 ± 11 vs. 135 ± 15 min, mean ± SE) or small intestine (133 + 10 vs. 137 ± 16 min) were not significantly (p > 0.4) altered by pancreatectomy, but the antral motility index (the sum of the antral contractions in a 15-min period) was greater after pancreatectomy (53 ± 6 vs. 27 ± 4; p < 0.05). Pancreatectomy led to undetectable plasma concentrations of pancreatic polypeptide, but had no effect on absolute concentrations of plasma motilin or on the cycling of plasma motilin in association with the duodenal migrating motor complex. We conclude that the pancreas and pancreatic polypeptide play little, if any, role in controlling canine interdigestive motility of the upper gut.

Original language	English (US)
Pages (from-to)	200-205
Number of pages	6
Journal	Gastroenterology
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/0016-5085(89)90781-6
State	Published - Jan 1989

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/0016-5085(89)90781-6

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title = "Role of the pancreas in the control of interdigestive gastrointestinal motility",

abstract = "Our aim was to determine if the pancreas regulates the interdigestive motor patterns of the upper gut. Four dogs were prepared with gastric and intestinal manometry catheters and interdigestive (fasting) motility was measured before and after total surgical pancreatectomy. The characteristics of the gastric and intestinal migrating motor complex were very similar before and after pancreatectomy. The time intervals between successive migrating motor complexes in the antrum (145 ± 11 vs. 135 ± 15 min, mean ± SE) or small intestine (133 + 10 vs. 137 ± 16 min) were not significantly (p > 0.4) altered by pancreatectomy, but the antral motility index (the sum of the antral contractions in a 15-min period) was greater after pancreatectomy (53 ± 6 vs. 27 ± 4; p < 0.05). Pancreatectomy led to undetectable plasma concentrations of pancreatic polypeptide, but had no effect on absolute concentrations of plasma motilin or on the cycling of plasma motilin in association with the duodenal migrating motor complex. We conclude that the pancreas and pancreatic polypeptide play little, if any, role in controlling canine interdigestive motility of the upper gut.",

author = "Peter Malfertheiner and Sarr, {Michael G.} and DiMagno, {Eugene P.}",

note = "Funding Information: Surgical procedures and subsequent care and conduct of experiments were performed after approval from the Animal Care Committee of the Mayo Foundation in accordance with the guidelines of the National Institutes of Health and Public Health Service Policy on the Humane Use and Care of Laboratory Animals. Four healthy female mongrel dogs (12-15 kg) were anesthetized with sodium thiopental 125 ngikg) and maintained with Fluothane (Ayerst Laboratories, New York, N.Y.). Using a short mid-line celiotomy, two manometric catheters were implanted in the antrum, two in the duodenum, and two along the proximal jejunum. These manometry catheters were cemented in a metal cannula that was imbedded in the abdominal wall. After a 2-wk postoperative recovery period, interdigestive motility was recorded on 4 separate days in each dog.",

year = "1989",

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doi = "10.1016/0016-5085(89)90781-6",

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AU - Sarr, Michael G.

AU - DiMagno, Eugene P.

N1 - Funding Information: Surgical procedures and subsequent care and conduct of experiments were performed after approval from the Animal Care Committee of the Mayo Foundation in accordance with the guidelines of the National Institutes of Health and Public Health Service Policy on the Humane Use and Care of Laboratory Animals. Four healthy female mongrel dogs (12-15 kg) were anesthetized with sodium thiopental 125 ngikg) and maintained with Fluothane (Ayerst Laboratories, New York, N.Y.). Using a short mid-line celiotomy, two manometric catheters were implanted in the antrum, two in the duodenum, and two along the proximal jejunum. These manometry catheters were cemented in a metal cannula that was imbedded in the abdominal wall. After a 2-wk postoperative recovery period, interdigestive motility was recorded on 4 separate days in each dog.

PY - 1989/1

Y1 - 1989/1

N2 - Our aim was to determine if the pancreas regulates the interdigestive motor patterns of the upper gut. Four dogs were prepared with gastric and intestinal manometry catheters and interdigestive (fasting) motility was measured before and after total surgical pancreatectomy. The characteristics of the gastric and intestinal migrating motor complex were very similar before and after pancreatectomy. The time intervals between successive migrating motor complexes in the antrum (145 ± 11 vs. 135 ± 15 min, mean ± SE) or small intestine (133 + 10 vs. 137 ± 16 min) were not significantly (p > 0.4) altered by pancreatectomy, but the antral motility index (the sum of the antral contractions in a 15-min period) was greater after pancreatectomy (53 ± 6 vs. 27 ± 4; p < 0.05). Pancreatectomy led to undetectable plasma concentrations of pancreatic polypeptide, but had no effect on absolute concentrations of plasma motilin or on the cycling of plasma motilin in association with the duodenal migrating motor complex. We conclude that the pancreas and pancreatic polypeptide play little, if any, role in controlling canine interdigestive motility of the upper gut.

AB - Our aim was to determine if the pancreas regulates the interdigestive motor patterns of the upper gut. Four dogs were prepared with gastric and intestinal manometry catheters and interdigestive (fasting) motility was measured before and after total surgical pancreatectomy. The characteristics of the gastric and intestinal migrating motor complex were very similar before and after pancreatectomy. The time intervals between successive migrating motor complexes in the antrum (145 ± 11 vs. 135 ± 15 min, mean ± SE) or small intestine (133 + 10 vs. 137 ± 16 min) were not significantly (p > 0.4) altered by pancreatectomy, but the antral motility index (the sum of the antral contractions in a 15-min period) was greater after pancreatectomy (53 ± 6 vs. 27 ± 4; p < 0.05). Pancreatectomy led to undetectable plasma concentrations of pancreatic polypeptide, but had no effect on absolute concentrations of plasma motilin or on the cycling of plasma motilin in association with the duodenal migrating motor complex. We conclude that the pancreas and pancreatic polypeptide play little, if any, role in controlling canine interdigestive motility of the upper gut.

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Role of the pancreas in the control of interdigestive gastrointestinal motility

Abstract

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