Role of the duodenum in postprandial release of pancreatic and gastrointestinal hormones

Peter Malfertheiner, Michael G. Sarr, Daniel K. Nelson, Eugene P. Dimagno

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

In previous studies we found that duodenec-tomy abolished the interdigestive cycles of plasma motilin and pancreatic polypeptide (PP). In the current studies, we tested the hypothesis that an intact duodenopancre-atic axis is necessary for normal postprandial release of pancreatic (PP, insulin) and gut peptides (gastric inhibi-tory peptide, GIP; cholecystokinin octapeptides, CCK-8; neurotensin; and gastrin). Consequently, we measured plasma concentration of pancreatic and gut hormones in normal and duodenectomized dogs after gavage feeding of a 250-ml liquid formula diet in conscious animals. After completing the experiments, pancreatic tissue concen-trations of PP and insulin were measured. Removal of the duodenum was associated with decreases in postprandialplasma concentrations of PP (p < 0.05) and insulin (p < 0. 05) and in pancreatic tissue concentrations of insulin (p = 0.01). Duodenectomy, however, did not alter post-prandial plasma concentrations of GIP, CCK-8, neuroten-sin, or gastrin nor pancreatic tissue concentrations of PP. These effects of duodenectomy may be due to disruption of duodenopancreatic neural connections or loss of vagus sensitive (non-GIP) humoral factors. Decreased post-prandial insulin concentrations may be due to lack of a neural or humoral insulinotropic factor arising from the duodenum.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalPancreas
Volume9
Issue number1
DOIs
StatePublished - Jan 1994

Keywords

  • CCK-8
  • Duodenectomy
  • Gastric inhibitory peptide
  • Gastrin
  • Insulin
  • Neurotensin
  • Pancreatic polypeptide
  • Pancreatic tissue hor-mone concentrations

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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