Role of the Common Fragile Sites in Cancers with a Human Papillomavirus Etiology

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5 Scopus citations

Abstract

High-risk human papillomaviruses (HPVs) are known to be associated with different anogenital cancers including cervical, anal, penile, and vaginal cancers. They are also found to be responsible for the dramatic increases in oropharyngeal squamous cell carcinoma (OPSCC) observed in the United States and Europe. The model for how high-risk HPVs induce cancer formation comes from studies of cervical cancer which usually involves integration of the HPV into the human genome and subsequent changes due to induced chromosomal instability. Recent work, discussed here, however suggests that this model may not be completely correct. In addition, we summarize studies now done in OPSCC which demonstrate that the role of HPV in these cancers may be different from that in cervical cancer. Finally, we propose new models for how HPV may be involved in the formation of these 2 cancers.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalCytogenetic and Genome Research
Volume150
Issue number3-4
DOIs
StatePublished - Mar 1 2017

Keywords

  • Cervical cancer • Common fragile sites • Human papillomavirus • Oropharyngeal squamous cell carcinoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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