Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans

Jacqueline Limberg, Blair D. Johnson, Michael T. Mozer, Walter W. Holbein, Timothy B. Curry, Nanduri R. Prabhakar, Michael J. Joyner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We examined the contribution of the carotid chemoreceptors to insulin-mediated increases in muscle sympathetic nerve activity (MSNA) in healthy humans. We hypothesized that reductions in carotid chemoreceptor activity would attenuate the sympathoexcitatory response to hyperinsulinemia. Young, healthy adults (9 male/9 female, 28 + 1 yr, 24 + 1 kg/m2) completed a 30-min euglycemic baseline followed by a 90-min hyperinsulinemic (1 mU•kg fat-free mass1•min1), euglycemic infusion. MSNA (microneurography of the peroneal nerve) was continuously measured. The role of the carotid chemoreceptors was assessed at baseline and during hyperinsulinemia via 1) acute hyperoxia, 2) low-dose dopamine (1–4 μg•kg1•min1), and 3) acute hyperoxia + low-dose dopamine. MSNA burst frequency increased from baseline during hyperinsulinemia (P < 0.01). Acute hyperoxia had no effect on MSNA burst frequency at rest (P = 0.74) or during hyperinsulinemia (P = 0.83). The insulin-mediated increase in MSNA burst frequency (P = 0.02) was unaffected by low-dose dopamine (P = 0.60). When combined with low-dose dopamine, acute hyperoxia had no effect on MSNA burst frequency at rest (P = 0.17) or during hyperinsulinemia (P 0.85). Carotid chemoreceptor desensitization in young, healthy men and women does not attenuate the sympathoexcitatory response to hyperinsulinemia. Our data suggest that the carotid chemoreceptors do not contribute to acute insulin-mediated increases in MSNA in young, healthy adults.

Original languageEnglish (US)
Pages (from-to)R173-R181
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume318
Issue number1
DOIs
StatePublished - Jan 2020

Keywords

  • Carotid body
  • Hyperinsulinemia
  • Muscle sympathetic nerve activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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