Role of Testing for Anticytoplasmic Autoantibodies in the Differential Diagnosis of Scleritis and Orbital Pseudotumor

PAUL H. KALINA; JAMES A. GARRITY; DAVID C. HERMAN; RICHARD A. DeREMEE; ULRICH SPECKS

doi:10.1016/S0025-6196(12)62724-4

Role of Testing for Anticytoplasmic Autoantibodies in the Differential Diagnosis of Scleritis and Orbital Pseudotumor

PAUL H. KALINA, JAMES A. GARRITY, DAVID C. HERMAN, RICHARD A. DeREMEE, ULRICH SPECKS

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Wegener's granulomatosis is a multisystem disease often with protean manifestations. Eye signs and symptoms can be prominent and may be the patient's initial complaint. For a definitive diagnosis of Wegener's granulomatosis, a tissue biopsy specimen must show vasculitis and necrotizing granuloma. The presence of anticytoplasmic autoantibodies in the serum of patients has been found to be highly specific for Wegener's granulomatosis and can considerably facilitate early diagnosis and be used to monitor disease activity. In two illustrative cases, the utility of this laboratory test in the differential diagnosis of scleritis and orbital pseudotumor is demonstrated.

Original language	English (US)
Pages (from-to)	1110-1117
Number of pages	8
Journal	Mayo Clinic proceedings
Volume	65
Issue number	8
DOIs	https://doi.org/10.1016/S0025-6196(12)62724-4
State	Published - 1990

ASJC Scopus subject areas

General Medicine

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title = "Role of Testing for Anticytoplasmic Autoantibodies in the Differential Diagnosis of Scleritis and Orbital Pseudotumor",

abstract = "Wegener's granulomatosis is a multisystem disease often with protean manifestations. Eye signs and symptoms can be prominent and may be the patient's initial complaint. For a definitive diagnosis of Wegener's granulomatosis, a tissue biopsy specimen must show vasculitis and necrotizing granuloma. The presence of anticytoplasmic autoantibodies in the serum of patients has been found to be highly specific for Wegener's granulomatosis and can considerably facilitate early diagnosis and be used to monitor disease activity. In two illustrative cases, the utility of this laboratory test in the differential diagnosis of scleritis and orbital pseudotumor is demonstrated.",

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AU - KALINA, PAUL H.

AU - GARRITY, JAMES A.

AU - HERMAN, DAVID C.

AU - DeREMEE, RICHARD A.

AU - SPECKS, ULRICH

PY - 1990

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N2 - Wegener's granulomatosis is a multisystem disease often with protean manifestations. Eye signs and symptoms can be prominent and may be the patient's initial complaint. For a definitive diagnosis of Wegener's granulomatosis, a tissue biopsy specimen must show vasculitis and necrotizing granuloma. The presence of anticytoplasmic autoantibodies in the serum of patients has been found to be highly specific for Wegener's granulomatosis and can considerably facilitate early diagnosis and be used to monitor disease activity. In two illustrative cases, the utility of this laboratory test in the differential diagnosis of scleritis and orbital pseudotumor is demonstrated.

AB - Wegener's granulomatosis is a multisystem disease often with protean manifestations. Eye signs and symptoms can be prominent and may be the patient's initial complaint. For a definitive diagnosis of Wegener's granulomatosis, a tissue biopsy specimen must show vasculitis and necrotizing granuloma. The presence of anticytoplasmic autoantibodies in the serum of patients has been found to be highly specific for Wegener's granulomatosis and can considerably facilitate early diagnosis and be used to monitor disease activity. In two illustrative cases, the utility of this laboratory test in the differential diagnosis of scleritis and orbital pseudotumor is demonstrated.

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Role of Testing for Anticytoplasmic Autoantibodies in the Differential Diagnosis of Scleritis and Orbital Pseudotumor

Abstract

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