Abstract
Objective: We performed a meta-analysis evaluating the use of fluorine-18-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in the diagnosis of cardiovascular implantable electronic device (CIED) infections. Background: PET/CT may be helpful in the diagnosis of CIED infection, particularly in patients with the absence of localizing signs or definitive echocardiographic findings. Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.govfrom January 1990 to April 2017 were searched for studies evaluating the accuracy of PET/CT in the diagnosis of CIED infections. Results: Overall, 14 studies involving 492 patients were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of CIED infection was 83% (95% CI 78%-86%) and the pooled specificity was 89% (95% CI 84%-94%). PET/CT demonstrated a higher sensitivity of 96% (95% CI 86%-99%) and specificity of 97% (95% CI 86%-99%) for diagnosis of pocket infections. Diagnostic accuracy for lead infections or CIED-IE was lower with pooled sensitivity of 76% (95% CI 65%-85%) and specificity of 83% (95% CI 72%-90%). Conclusion: Use of PET/CT in the evaluation of CIED infection has both a high sensitivity (83%) and specificity (89%) and deserves consideration in the management of selected patients with suspected CIED infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-13 |
| Number of pages | 13 |
| Journal | Journal of Nuclear Cardiology |
| DOIs | |
| State | Accepted/In press - Sep 14 2017 |
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Keywords
- CIED
- imaging
- infection
- meta-analysis
- PET
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
Role of 18F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections : A meta-analysis. / Mahmood, Maryam; Tuba Kendi, Ayse; Farid, Saira; Ajmal, Saira; Johnson, Geoffrey B; Baddour, Larry M.; Chareonthaitawee, Panithaya; Friedman, Paul Andrew; Sohail, M. Rizwan.
In: Journal of Nuclear Cardiology, 14.09.2017, p. 1-13.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of 18F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections
T2 - A meta-analysis
AU - Mahmood, Maryam
AU - Tuba Kendi, Ayse
AU - Farid, Saira
AU - Ajmal, Saira
AU - Johnson, Geoffrey B
AU - Baddour, Larry M.
AU - Chareonthaitawee, Panithaya
AU - Friedman, Paul Andrew
AU - Sohail, M. Rizwan
PY - 2017/9/14
Y1 - 2017/9/14
N2 - Objective: We performed a meta-analysis evaluating the use of fluorine-18-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in the diagnosis of cardiovascular implantable electronic device (CIED) infections. Background: PET/CT may be helpful in the diagnosis of CIED infection, particularly in patients with the absence of localizing signs or definitive echocardiographic findings. Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.govfrom January 1990 to April 2017 were searched for studies evaluating the accuracy of PET/CT in the diagnosis of CIED infections. Results: Overall, 14 studies involving 492 patients were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of CIED infection was 83% (95% CI 78%-86%) and the pooled specificity was 89% (95% CI 84%-94%). PET/CT demonstrated a higher sensitivity of 96% (95% CI 86%-99%) and specificity of 97% (95% CI 86%-99%) for diagnosis of pocket infections. Diagnostic accuracy for lead infections or CIED-IE was lower with pooled sensitivity of 76% (95% CI 65%-85%) and specificity of 83% (95% CI 72%-90%). Conclusion: Use of PET/CT in the evaluation of CIED infection has both a high sensitivity (83%) and specificity (89%) and deserves consideration in the management of selected patients with suspected CIED infections.
AB - Objective: We performed a meta-analysis evaluating the use of fluorine-18-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in the diagnosis of cardiovascular implantable electronic device (CIED) infections. Background: PET/CT may be helpful in the diagnosis of CIED infection, particularly in patients with the absence of localizing signs or definitive echocardiographic findings. Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.govfrom January 1990 to April 2017 were searched for studies evaluating the accuracy of PET/CT in the diagnosis of CIED infections. Results: Overall, 14 studies involving 492 patients were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of CIED infection was 83% (95% CI 78%-86%) and the pooled specificity was 89% (95% CI 84%-94%). PET/CT demonstrated a higher sensitivity of 96% (95% CI 86%-99%) and specificity of 97% (95% CI 86%-99%) for diagnosis of pocket infections. Diagnostic accuracy for lead infections or CIED-IE was lower with pooled sensitivity of 76% (95% CI 65%-85%) and specificity of 83% (95% CI 72%-90%). Conclusion: Use of PET/CT in the evaluation of CIED infection has both a high sensitivity (83%) and specificity (89%) and deserves consideration in the management of selected patients with suspected CIED infections.
KW - CIED
KW - imaging
KW - infection
KW - meta-analysis
KW - PET
UR - http://www.scopus.com/inward/record.url?scp=85029497125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029497125&partnerID=8YFLogxK
U2 - 10.1007/s12350-017-1063-0
DO - 10.1007/s12350-017-1063-0
M3 - Article
C2 - 28913626
AN - SCOPUS:85029497125
SP - 1
EP - 13
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
ER -