Role of 18F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections: A meta-analysis

Maryam Mahmood, Ayse Tuba Kendi, Saira Farid, Saira Ajmal, Geoffrey B Johnson, Larry M. Baddour, Panithaya Chareonthaitawee, Paul Andrew Friedman, M. Rizwan Sohail

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: We performed a meta-analysis evaluating the use of fluorine-18-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in the diagnosis of cardiovascular implantable electronic device (CIED) infections. Background: PET/CT may be helpful in the diagnosis of CIED infection, particularly in patients with the absence of localizing signs or definitive echocardiographic findings. Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.govfrom January 1990 to April 2017 were searched for studies evaluating the accuracy of PET/CT in the diagnosis of CIED infections. Results: Overall, 14 studies involving 492 patients were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of CIED infection was 83% (95% CI 78%-86%) and the pooled specificity was 89% (95% CI 84%-94%). PET/CT demonstrated a higher sensitivity of 96% (95% CI 86%-99%) and specificity of 97% (95% CI 86%-99%) for diagnosis of pocket infections. Diagnostic accuracy for lead infections or CIED-IE was lower with pooled sensitivity of 76% (95% CI 65%-85%) and specificity of 83% (95% CI 72%-90%). Conclusion: Use of PET/CT in the evaluation of CIED infection has both a high sensitivity (83%) and specificity (89%) and deserves consideration in the management of selected patients with suspected CIED infections.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalJournal of Nuclear Cardiology
DOIs
StateAccepted/In press - Sep 14 2017

Fingerprint

Fluorodeoxyglucose F18
Meta-Analysis
Equipment and Supplies
Infection
Cardiovascular Infections
Positron Emission Tomography Computed Tomography
PubMed
Libraries
Sensitivity and Specificity

Keywords

  • CIED
  • imaging
  • infection
  • meta-analysis
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Role of 18F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections : A meta-analysis. / Mahmood, Maryam; Tuba Kendi, Ayse; Farid, Saira; Ajmal, Saira; Johnson, Geoffrey B; Baddour, Larry M.; Chareonthaitawee, Panithaya; Friedman, Paul Andrew; Sohail, M. Rizwan.

In: Journal of Nuclear Cardiology, 14.09.2017, p. 1-13.

Research output: Contribution to journalArticle

Mahmood, Maryam ; Tuba Kendi, Ayse ; Farid, Saira ; Ajmal, Saira ; Johnson, Geoffrey B ; Baddour, Larry M. ; Chareonthaitawee, Panithaya ; Friedman, Paul Andrew ; Sohail, M. Rizwan. / Role of 18F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections : A meta-analysis. In: Journal of Nuclear Cardiology. 2017 ; pp. 1-13.
@article{8a12d7e240904014a0eee4840bf250a1,
title = "Role of 18F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections: A meta-analysis",
abstract = "Objective: We performed a meta-analysis evaluating the use of fluorine-18-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in the diagnosis of cardiovascular implantable electronic device (CIED) infections. Background: PET/CT may be helpful in the diagnosis of CIED infection, particularly in patients with the absence of localizing signs or definitive echocardiographic findings. Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.govfrom January 1990 to April 2017 were searched for studies evaluating the accuracy of PET/CT in the diagnosis of CIED infections. Results: Overall, 14 studies involving 492 patients were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of CIED infection was 83{\%} (95{\%} CI 78{\%}-86{\%}) and the pooled specificity was 89{\%} (95{\%} CI 84{\%}-94{\%}). PET/CT demonstrated a higher sensitivity of 96{\%} (95{\%} CI 86{\%}-99{\%}) and specificity of 97{\%} (95{\%} CI 86{\%}-99{\%}) for diagnosis of pocket infections. Diagnostic accuracy for lead infections or CIED-IE was lower with pooled sensitivity of 76{\%} (95{\%} CI 65{\%}-85{\%}) and specificity of 83{\%} (95{\%} CI 72{\%}-90{\%}). Conclusion: Use of PET/CT in the evaluation of CIED infection has both a high sensitivity (83{\%}) and specificity (89{\%}) and deserves consideration in the management of selected patients with suspected CIED infections.",
keywords = "CIED, imaging, infection, meta-analysis, PET",
author = "Maryam Mahmood and {Tuba Kendi}, Ayse and Saira Farid and Saira Ajmal and Johnson, {Geoffrey B} and Baddour, {Larry M.} and Panithaya Chareonthaitawee and Friedman, {Paul Andrew} and Sohail, {M. Rizwan}",
year = "2017",
month = "9",
day = "14",
doi = "10.1007/s12350-017-1063-0",
language = "English (US)",
pages = "1--13",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",

}

TY - JOUR

T1 - Role of 18F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections

T2 - A meta-analysis

AU - Mahmood, Maryam

AU - Tuba Kendi, Ayse

AU - Farid, Saira

AU - Ajmal, Saira

AU - Johnson, Geoffrey B

AU - Baddour, Larry M.

AU - Chareonthaitawee, Panithaya

AU - Friedman, Paul Andrew

AU - Sohail, M. Rizwan

PY - 2017/9/14

Y1 - 2017/9/14

N2 - Objective: We performed a meta-analysis evaluating the use of fluorine-18-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in the diagnosis of cardiovascular implantable electronic device (CIED) infections. Background: PET/CT may be helpful in the diagnosis of CIED infection, particularly in patients with the absence of localizing signs or definitive echocardiographic findings. Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.govfrom January 1990 to April 2017 were searched for studies evaluating the accuracy of PET/CT in the diagnosis of CIED infections. Results: Overall, 14 studies involving 492 patients were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of CIED infection was 83% (95% CI 78%-86%) and the pooled specificity was 89% (95% CI 84%-94%). PET/CT demonstrated a higher sensitivity of 96% (95% CI 86%-99%) and specificity of 97% (95% CI 86%-99%) for diagnosis of pocket infections. Diagnostic accuracy for lead infections or CIED-IE was lower with pooled sensitivity of 76% (95% CI 65%-85%) and specificity of 83% (95% CI 72%-90%). Conclusion: Use of PET/CT in the evaluation of CIED infection has both a high sensitivity (83%) and specificity (89%) and deserves consideration in the management of selected patients with suspected CIED infections.

AB - Objective: We performed a meta-analysis evaluating the use of fluorine-18-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in the diagnosis of cardiovascular implantable electronic device (CIED) infections. Background: PET/CT may be helpful in the diagnosis of CIED infection, particularly in patients with the absence of localizing signs or definitive echocardiographic findings. Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.govfrom January 1990 to April 2017 were searched for studies evaluating the accuracy of PET/CT in the diagnosis of CIED infections. Results: Overall, 14 studies involving 492 patients were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of CIED infection was 83% (95% CI 78%-86%) and the pooled specificity was 89% (95% CI 84%-94%). PET/CT demonstrated a higher sensitivity of 96% (95% CI 86%-99%) and specificity of 97% (95% CI 86%-99%) for diagnosis of pocket infections. Diagnostic accuracy for lead infections or CIED-IE was lower with pooled sensitivity of 76% (95% CI 65%-85%) and specificity of 83% (95% CI 72%-90%). Conclusion: Use of PET/CT in the evaluation of CIED infection has both a high sensitivity (83%) and specificity (89%) and deserves consideration in the management of selected patients with suspected CIED infections.

KW - CIED

KW - imaging

KW - infection

KW - meta-analysis

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=85029497125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029497125&partnerID=8YFLogxK

U2 - 10.1007/s12350-017-1063-0

DO - 10.1007/s12350-017-1063-0

M3 - Article

C2 - 28913626

AN - SCOPUS:85029497125

SP - 1

EP - 13

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -