Role of structural MRI in Alzheimer's disease

Prashanthi Vemuri; Clifford R. Jack

doi:10.1186/alzrt47

Role of structural MRI in Alzheimer's disease

Prashanthi Vemuri, Clifford R. Jack

Radiology

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which sMRI can be used as an AD biomarker, and (c) comparisons of sMRI with other major AD biomarkers.

Original language	English (US)
Article number	23
Journal	Alzheimer's Research and Therapy
Volume	2
Issue number	4
DOIs	https://doi.org/10.1186/alzrt47
State	Published - 2010

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cognitive Neuroscience

Access to Document

10.1186/alzrt47

Cite this

@article{53e023a919b340e1b934220c9a89f1c8,

title = "Role of structural MRI in Alzheimer's disease",

abstract = "Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which sMRI can be used as an AD biomarker, and (c) comparisons of sMRI with other major AD biomarkers.",

author = "Prashanthi Vemuri and Jack, {Clifford R.}",

note = "Funding Information: PV receives support from the Robert H. Smith Family Foundation Research Fellowship. CRJ receives support from the National Institute on Aging – AG11378 (PI), P50-AG16574 (Co-I), and U01 AG024904-01 (Co-I) – and the Alexander Family Alzheimer{\textquoteright}s Disease Research Professorship of the Mayo Foundation.",

year = "2010",

doi = "10.1186/alzrt47",

language = "English (US)",

volume = "2",

journal = "Alzheimer's Research and Therapy",

issn = "1758-9193",

publisher = "BioMed Central",

number = "4",

}

TY - JOUR

T1 - Role of structural MRI in Alzheimer's disease

AU - Vemuri, Prashanthi

AU - Jack, Clifford R.

N1 - Funding Information: PV receives support from the Robert H. Smith Family Foundation Research Fellowship. CRJ receives support from the National Institute on Aging – AG11378 (PI), P50-AG16574 (Co-I), and U01 AG024904-01 (Co-I) – and the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Foundation.

PY - 2010

Y1 - 2010

N2 - Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which sMRI can be used as an AD biomarker, and (c) comparisons of sMRI with other major AD biomarkers.

AB - Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which sMRI can be used as an AD biomarker, and (c) comparisons of sMRI with other major AD biomarkers.

UR - http://www.scopus.com/inward/record.url?scp=77956301807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956301807&partnerID=8YFLogxK

U2 - 10.1186/alzrt47

DO - 10.1186/alzrt47

M3 - Review article

C2 - 20807454

AN - SCOPUS:77956301807

SN - 1758-9193

VL - 2

JO - Alzheimer's Research and Therapy

JF - Alzheimer's Research and Therapy

IS - 4

M1 - 23

ER -

Role of structural MRI in Alzheimer's disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this