Role of radiation therapy and fluoropyrimidines in the treatment of gastrointestinal malignancies

W. W. Wong, S. E. Schild, J. A. Martenson

Research output: Contribution to journalArticle

Abstract

Background: The use of combined chemotherapy and radiation for gastrointestinal malignancies has several theoretical advantages, and clinical trials to determine the type and extent of clinical benefits have been performed. Methods: The basic science and clinical trial data evaluating such combinations are reviewed, with an emphasis on the interactions between fluoropyrimidines and radiation. Results: Improved outcomes from chemoradiotherapy have been demonstrated in patients with selected stages of anal, esophageal, rectal, and pancreatic cancer. Conclusion: Despite these positive results, further work is needed to demonstrate even more effective and less toxic treatment regimens.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalCancer Control
Volume3
Issue number4
StatePublished - 1996

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Radiotherapy
Clinical Trials
Radiation
Anus Neoplasms
Poisons
Chemoradiotherapy
Esophageal Neoplasms
Rectal Neoplasms
Pancreatic Neoplasms
Neoplasms
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Wong, W. W., Schild, S. E., & Martenson, J. A. (1996). Role of radiation therapy and fluoropyrimidines in the treatment of gastrointestinal malignancies. Cancer Control, 3(4), 319-328.

Role of radiation therapy and fluoropyrimidines in the treatment of gastrointestinal malignancies. / Wong, W. W.; Schild, S. E.; Martenson, J. A.

In: Cancer Control, Vol. 3, No. 4, 1996, p. 319-328.

Research output: Contribution to journalArticle

Wong, WW, Schild, SE & Martenson, JA 1996, 'Role of radiation therapy and fluoropyrimidines in the treatment of gastrointestinal malignancies', Cancer Control, vol. 3, no. 4, pp. 319-328.
Wong, W. W. ; Schild, S. E. ; Martenson, J. A. / Role of radiation therapy and fluoropyrimidines in the treatment of gastrointestinal malignancies. In: Cancer Control. 1996 ; Vol. 3, No. 4. pp. 319-328.
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