Role of radiation therapy and fluoropyrimidines in the treatment of gastrointestinal malignancies

W. W. Wong, S. E. Schild, J. A. Martenson

Research output: Contribution to journalReview article

Abstract

Background: The use of combined chemotherapy and radiation for gastrointestinal malignancies has several theoretical advantages, and clinical trials to determine the type and extent of clinical benefits have been performed. Methods: The basic science and clinical trial data evaluating such combinations are reviewed, with an emphasis on the interactions between fluoropyrimidines and radiation. Results: Improved outcomes from chemoradiotherapy have been demonstrated in patients with selected stages of anal, esophageal, rectal, and pancreatic cancer. Conclusion: Despite these positive results, further work is needed to demonstrate even more effective and less toxic treatment regimens.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalCancer Control
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Hematology
  • Oncology

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