Role of prostaglandins and renal nerves in the renal actions of adrenomedullin

Michihisa Jougasaki, Lawrence L. Aarhus, Denise M. Heublein, Sharon M. Sandberg, John C. Burnett

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Adrenomedullin (ADM), originally discovered in human pheochromocytoma, is also of renal cell origin and has natriuretic and diuretic actions. The present study was designed to investigate the role of prostaglandins and renal nerves in the renal hemodynamic and natriuretic actions of ADM.ADM was administered intrarenally (1, 5 and 25 ng·kg-1·min-1) with and without prostaglandin inhibition (meclofenamate, 5 mg/kg intravenous bolus) in anesthetized normal mongrel dogs (n = 5, each). To elucidate the role of renal nerves, ADM was administered intrarenally to the denervated kidney in five dogs. ADM mediated a natriuretic action via increases in glomerular filtration rate and decreases in distal tubular sodium reabsorption, which was attenuated by renal denervation and completely abolished by prostaglandin inhibition. The renal vasodilatation induced by ADM was attenuated by meclofenamate, as well as by renal denervation, although not significantly. Additionally, renal nerves mediated hemodynamic effects of hypertension that were produced by intrarenal infusion of ADM. This study establishes an important mechanistic role for renal prostaglandins as a mediator of ADM-mediated natriuresis at the level of the glomerulus and terminal nephron.

Original languageEnglish (US)
Pages (from-to)F260-F266
JournalAmerican Journal of Physiology - Renal Physiology
Volume272
Issue number2 41-2
DOIs
StatePublished - Feb 1997

Keywords

  • Adenosine 3',5'-cyclic monophosphate
  • Distal tubular function
  • Natriuretic peptide
  • Sodium excretion

ASJC Scopus subject areas

  • Physiology
  • Urology

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