Role of plasmapheresis in thrombocytopenic purpura associated with Waldenstrom's macroglobulinemia

Tushar C Patel, S. B. Moore, A. A. Pineda, T. E. Witzig

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 67-year-old man with Waldenstrom's macroglobulinemia had a relapse of chronic idiopathic thrombocytopenic purpura (ITP), which had been refractory to corticosteroids, splenectomy, vinca alkaloids, and high-dose intravenous γ-globulin therapy. A biclonal gammopathy (IgM κ and IgG λ) was detected in his serum and was likely responsible for his refractory thrombocytopenia. He was treated with chlorambucil and prednisone. Plasmapheresis was effective in temporarily maintaining platelet counts and in decreasing morbidity until immunosuppression was completely effective against the production of the monoclonal protein. The previously reported experiences with use of plasmapheresis in patients with chronic ITP are discussed. Plasmapheresis may be of value in the treatment of selected patients with severe ITP and monoclonal gammopathy.

Original languageEnglish (US)
Pages (from-to)597-600
Number of pages4
JournalMayo Clinic Proceedings
Volume71
Issue number6
StatePublished - 1996

Fingerprint

Thrombocytopenic Purpura
Waldenstrom Macroglobulinemia
Idiopathic Thrombocytopenic Purpura
Plasmapheresis
Vinca Alkaloids
Chlorambucil
Paraproteinemias
Globulins
Splenectomy
Prednisone
Platelet Count
Thrombocytopenia
Immunosuppression
Immunoglobulin M
Adrenal Cortex Hormones
Immunoglobulin G
Morbidity
Recurrence
Therapeutics
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Role of plasmapheresis in thrombocytopenic purpura associated with Waldenstrom's macroglobulinemia. / Patel, Tushar C; Moore, S. B.; Pineda, A. A.; Witzig, T. E.

In: Mayo Clinic Proceedings, Vol. 71, No. 6, 1996, p. 597-600.

Research output: Contribution to journalArticle

Patel, Tushar C ; Moore, S. B. ; Pineda, A. A. ; Witzig, T. E. / Role of plasmapheresis in thrombocytopenic purpura associated with Waldenstrom's macroglobulinemia. In: Mayo Clinic Proceedings. 1996 ; Vol. 71, No. 6. pp. 597-600.
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