Abstract
As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.
Original language | English (US) |
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Pages (from-to) | 612-613 |
Number of pages | 2 |
Journal | Experimental Gerontology |
Volume | 48 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2013 |
Keywords
- Aging
- Atherosclerosis
- Cancer
- Insulin-like growth factors
- Pregnancy-associated plasma protein-A
ASJC Scopus subject areas
- Biochemistry
- Aging
- Molecular Biology
- Genetics
- Endocrinology
- Cell Biology