Abstract
As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 612-613 |
| Number of pages | 2 |
| Journal | Experimental Gerontology |
| Volume | 48 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2013 |
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Keywords
- Aging
- Atherosclerosis
- Cancer
- Insulin-like growth factors
- Pregnancy-associated plasma protein-A
ASJC Scopus subject areas
- Aging
- Biochemistry
- Cell Biology
- Endocrinology
- Genetics
- Molecular Biology
Cite this
Role of PAPP-A in aging and age-related disease. / Conover, Cheryl A.
In: Experimental Gerontology, Vol. 48, No. 7, 07.2013, p. 612-613.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of PAPP-A in aging and age-related disease
AU - Conover, Cheryl A
PY - 2013/7
Y1 - 2013/7
N2 - As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.
AB - As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.
KW - Aging
KW - Atherosclerosis
KW - Cancer
KW - Insulin-like growth factors
KW - Pregnancy-associated plasma protein-A
UR - http://www.scopus.com/inward/record.url?scp=84879005641&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879005641&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2012.06.017
DO - 10.1016/j.exger.2012.06.017
M3 - Article
C2 - 22790018
AN - SCOPUS:84879005641
VL - 48
SP - 612
EP - 613
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 7
ER -