Role of PAPP-A in aging and age-related disease

Cheryl A. Conover

doi:10.1016/j.exger.2012.06.017

Role of PAPP-A in aging and age-related disease

Cheryl A. Conover

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.

Original language	English (US)
Pages (from-to)	612-613
Number of pages	2
Journal	Experimental Gerontology
Volume	48
Issue number	7
DOIs	https://doi.org/10.1016/j.exger.2012.06.017
State	Published - Jul 2013

Keywords

Aging
Atherosclerosis
Cancer
Insulin-like growth factors
Pregnancy-associated plasma protein-A

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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Conover, C. A. (2013). Role of PAPP-A in aging and age-related disease. Experimental Gerontology, 48(7), 612-613. https://doi.org/10.1016/j.exger.2012.06.017

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