Role of PAPP-A in aging and age-related disease

Cheryl A. Conover

doi:10.1016/j.exger.2012.06.017

Role of PAPP-A in aging and age-related disease

Cheryl A. Conover

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.

Original language	English (US)
Pages (from-to)	612-613
Number of pages	2
Journal	Experimental Gerontology
Volume	48
Issue number	7
DOIs	https://doi.org/10.1016/j.exger.2012.06.017
State	Published - Jul 2013

Keywords

Aging
Atherosclerosis
Cancer
Insulin-like growth factors
Pregnancy-associated plasma protein-A

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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title = "Role of PAPP-A in aging and age-related disease",

abstract = "As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.",

keywords = "Aging, Atherosclerosis, Cancer, Insulin-like growth factors, Pregnancy-associated plasma protein-A",

author = "Conover, {Cheryl A.}",

note = "Funding Information: This work was supported by National Institutes of Health Grants HL074871 and AG028141 , and a Senior Scholar Award from the Ellison Medical Foundation .",

year = "2013",

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N1 - Funding Information: This work was supported by National Institutes of Health Grants HL074871 and AG028141 , and a Senior Scholar Award from the Ellison Medical Foundation .

PY - 2013/7

Y1 - 2013/7

N2 - As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.

AB - As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.

KW - Aging

KW - Atherosclerosis

KW - Cancer

KW - Insulin-like growth factors

KW - Pregnancy-associated plasma protein-A

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Role of PAPP-A in aging and age-related disease

Abstract

Keywords

ASJC Scopus subject areas

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