Role of pancreatic fat in the outcomes of pancreatitis

Chathur Acharya, Sarah Navina, Vijay Prem Singh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The role of obesity in relation to various disease processes is being increasingly studied, with reports over the last several years increasingly mentioning its association with worse outcomes in acute disease. Obesity has also gained recognition as a risk factor for severe acute pancreatitis (SAP).The mortality in SAP may be as high as 30% and is usually attributable to multi system organ failure (MSOF) earlier in the disease, and complications of necrotizing pancreatitis later [9-11]. To date there is no specific treatment for acute pancreatitis (AP) and the management is largely expectant and supportive. Obesity in general has also been associated with poor outcomes in sepsis and other pathological states including trauma and burns. With the role of unsaturated fatty acids (UFA) as propagators in SAP having recently come to light and with the recognition of acute lipotoxicity, there is now an opportunity to explore different strategies to reduce the mortality and morbidity in SAP and potentially other disease states associated with such a pathophysiology. In this review we will discuss the role of fat and implications of the consequent acute lipotoxicity on the outcomes of acute pancreatitis in lean and obese states and during acute on chronic pancreatitis.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalPancreatology
Volume14
Issue number5
DOIs
StatePublished - Sep 1 2014

Fingerprint

Pancreatitis
Fats
Obesity
Mortality
Chronic Pancreatitis
Acute Disease
Unsaturated Fatty Acids
Burns
Sepsis
Morbidity
Wounds and Injuries

Keywords

  • Fibrosis
  • Lipotoxicity
  • Multi system organ failure
  • Obesity
  • Outcomes
  • Pancreatitis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

Cite this

Role of pancreatic fat in the outcomes of pancreatitis. / Acharya, Chathur; Navina, Sarah; Singh, Vijay Prem.

In: Pancreatology, Vol. 14, No. 5, 01.09.2014, p. 403-408.

Research output: Contribution to journalArticle

Acharya, Chathur ; Navina, Sarah ; Singh, Vijay Prem. / Role of pancreatic fat in the outcomes of pancreatitis. In: Pancreatology. 2014 ; Vol. 14, No. 5. pp. 403-408.
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