TY - JOUR
T1 - Role of microenvironment in non-hodgkin lymphoma
T2 - Understanding the composition and biology
AU - Khurana, Arushi
AU - Ansell, Stephen M.
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Lymphoma microenvironment is a dynamic and well-orchestrated network of various immune and stromal cells that is indispensable for tumor cell survival, growth, migration, immune escape, and drug resistance. Recent progress has enhanced our knowledge of the pivotal role of microenvironment in lymphomagenesis. Understanding the characteristics, functions, and contributions of various components of the tumor niche, along with its bidirectional interactions with tumor cells, is paramount. It offers the potential to identify new therapeutic targets with the ability to restore antitumor immune surveillance and eliminate the protumoral factors contributed by the tumor niche.
AB - Lymphoma microenvironment is a dynamic and well-orchestrated network of various immune and stromal cells that is indispensable for tumor cell survival, growth, migration, immune escape, and drug resistance. Recent progress has enhanced our knowledge of the pivotal role of microenvironment in lymphomagenesis. Understanding the characteristics, functions, and contributions of various components of the tumor niche, along with its bidirectional interactions with tumor cells, is paramount. It offers the potential to identify new therapeutic targets with the ability to restore antitumor immune surveillance and eliminate the protumoral factors contributed by the tumor niche.
KW - Immune escape
KW - lymphomagenesis
KW - non-Hodgkin lymphoma
KW - tumor microenvironment
KW - tumor niche
UR - http://www.scopus.com/inward/record.url?scp=85086008234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086008234&partnerID=8YFLogxK
U2 - 10.1097/PPO.0000000000000446
DO - 10.1097/PPO.0000000000000446
M3 - Review article
C2 - 32496454
AN - SCOPUS:85086008234
SN - 1528-9117
VL - 26
SP - 206
EP - 216
JO - Cancer Journal (United States)
JF - Cancer Journal (United States)
IS - 3
ER -