Role of MHC, Mls and TCR in immune tolerance

G. Anderson, C. David

Research output: Contribution to journalArticle

Abstract

MHC class II molecules and self antigens, such as Mls, influence T-cell selection by clonal deletion of potentially self-reactive T cells. In order to examine the role of various class II molecules in the T-cell receptor-self antigen interaction, class II transgenic and recombinant mice were analysed for TCR expression. Our studies indicate that the A(α) and E(α) chains can present Mls gene products for the clonal deletion of V(β)6-bearing T cells, and that the A(α)(q) chain is defective in this process. We have also shown that E(α)A(β) heterodimer in transgenic and recombinant mice is expressed and functions to delete I-E reactive V(β)11 T cells, demonstrating again the role of the E(α) molecule.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalJournal of Immunogenetics
Volume16
Issue number4-5
StatePublished - 1989

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Immune Tolerance
Clonal Deletion
T-Lymphocytes
Autoantigens
Transgenic Mice
Histocompatibility Antigens Class II
T-Cell Antigen Receptor
Genes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Anderson, G., & David, C. (1989). Role of MHC, Mls and TCR in immune tolerance. Journal of Immunogenetics, 16(4-5), 257-261.

Role of MHC, Mls and TCR in immune tolerance. / Anderson, G.; David, C.

In: Journal of Immunogenetics, Vol. 16, No. 4-5, 1989, p. 257-261.

Research output: Contribution to journalArticle

Anderson, G & David, C 1989, 'Role of MHC, Mls and TCR in immune tolerance', Journal of Immunogenetics, vol. 16, no. 4-5, pp. 257-261.
Anderson G, David C. Role of MHC, Mls and TCR in immune tolerance. Journal of Immunogenetics. 1989;16(4-5):257-261.
Anderson, G. ; David, C. / Role of MHC, Mls and TCR in immune tolerance. In: Journal of Immunogenetics. 1989 ; Vol. 16, No. 4-5. pp. 257-261.
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