ROLE OF MHC, Mls AND TCR IN IMMUNE TOLERANCE

G. Anderson, C. David

Research output: Contribution to journalArticle

Abstract

MHC class II molecules and self antigens, such as Mls, influence T‐cell selection by clonal deletion of potentially self‐reactive T cells. In order to examine the role of various class II molecules in the T‐cell receptor‐self antigen interaction, class II transgenic and recombinant mice were analysed for TCR expression. Our studies indicate that the Aα and Eα chains can present Mls gene products for the clonal deletion of Vβ6‐bearing T cells, and that the Aαq chain is defective in this process. We have also shown that Eα Aβ heterodimer in transgenic and recombinant mice is expressed and functions to delete I‐E reactive Vβ11 T cells, demonstrating again the role of the Eα molecule.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalInternational Journal of Immunogenetics
Volume16
Issue number4-5
DOIs
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'ROLE OF MHC, Mls AND TCR IN IMMUNE TOLERANCE'. Together they form a unique fingerprint.

  • Cite this