TY - JOUR
T1 - ROLE OF MHC, Mls AND TCR IN IMMUNE TOLERANCE
AU - Anderson, G.
AU - David, C.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/8
Y1 - 1989/8
N2 - MHC class II molecules and self antigens, such as Mls, influence T‐cell selection by clonal deletion of potentially self‐reactive T cells. In order to examine the role of various class II molecules in the T‐cell receptor‐self antigen interaction, class II transgenic and recombinant mice were analysed for TCR expression. Our studies indicate that the Aα and Eα chains can present Mls gene products for the clonal deletion of Vβ6‐bearing T cells, and that the Aαq chain is defective in this process. We have also shown that Eα Aβ heterodimer in transgenic and recombinant mice is expressed and functions to delete I‐E reactive Vβ11 T cells, demonstrating again the role of the Eα molecule.
AB - MHC class II molecules and self antigens, such as Mls, influence T‐cell selection by clonal deletion of potentially self‐reactive T cells. In order to examine the role of various class II molecules in the T‐cell receptor‐self antigen interaction, class II transgenic and recombinant mice were analysed for TCR expression. Our studies indicate that the Aα and Eα chains can present Mls gene products for the clonal deletion of Vβ6‐bearing T cells, and that the Aαq chain is defective in this process. We have also shown that Eα Aβ heterodimer in transgenic and recombinant mice is expressed and functions to delete I‐E reactive Vβ11 T cells, demonstrating again the role of the Eα molecule.
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U2 - 10.1111/j.1744-313X.1989.tb00471.x
DO - 10.1111/j.1744-313X.1989.tb00471.x
M3 - Article
C2 - 2517948
AN - SCOPUS:0024951028
SN - 1744-3121
VL - 16
SP - 257
EP - 261
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
IS - 4-5
ER -