Role of Mass Spectrometry in Clinical Endocrinology

Siva S. Ketha; Ravinder J. Singh; Hemamalini Ketha

doi:10.1016/j.ecl.2017.04.001

Role of Mass Spectrometry in Clinical Endocrinology

Siva S. Ketha, Ravinder J. Singh, Hemamalini Ketha

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes.

Original language	English (US)
Pages (from-to)	593-613
Number of pages	21
Journal	Endocrinology and Metabolism Clinics of North America
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.ecl.2017.04.001
State	Published - Sep 2017

Keywords

IGF1 by mass spectrometry
Liquid chromatography mass spectrometry in clinical endocrinology
Liquid chromatography tandem mass spectrometry
Steroid Liquid chromatography tandem mass spectrometry

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ecl.2017.04.001

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title = "Role of Mass Spectrometry in Clinical Endocrinology",

abstract = "The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes.",

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author = "Ketha, {Siva S.} and Singh, {Ravinder J.} and Hemamalini Ketha",

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AU - Singh, Ravinder J.

AU - Ketha, Hemamalini

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N2 - The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes.

AB - The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes.

KW - IGF1 by mass spectrometry

KW - Liquid chromatography mass spectrometry in clinical endocrinology

KW - Liquid chromatography tandem mass spectrometry

KW - Steroid Liquid chromatography tandem mass spectrometry

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Role of Mass Spectrometry in Clinical Endocrinology

Abstract

Keywords

ASJC Scopus subject areas

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