Role of Mass Spectrometry in Clinical Endocrinology

Siva S. Ketha, Ravinder J. Singh, Hemamalini Ketha

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes.

Original languageEnglish (US)
Pages (from-to)593-613
Number of pages21
JournalEndocrinology and Metabolism Clinics of North America
Volume46
Issue number3
DOIs
StatePublished - Sep 2017

Keywords

  • IGF1 by mass spectrometry
  • Liquid chromatography mass spectrometry in clinical endocrinology
  • Liquid chromatography tandem mass spectrometry
  • Steroid Liquid chromatography tandem mass spectrometry

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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