Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma

Ahmad M. Mansour; J. Fernando Arevalo; Eman Al Kahtani; Hernando Zegarra; Emad Abboud; Rajiv Anand; Hamid Ahmadieh; Robert A. Sisk; Salman Mirza; Samuray Tuncer; Amparo Navea Tejerina; Jorge Mataix; Francisco J. Ascaso; Jose S. Pulido; Rainer Guthoff; Winfried Goebel; Young Jung Roh; Alay S. Banker; Ronald C. Gentile; Isabel Alonso Martinez; Rodney Morris; Neeraj Panday; Park Jung Min; Emilie Mercé; Timothy Y.Y. Lai; Vicky Massoud; Nicola G. Ghazi

doi:10.1155/2014/210458

Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma

Ahmad M. Mansour, J. Fernando Arevalo, Eman Al Kahtani, Hernando Zegarra, Emad Abboud, Rajiv Anand, Hamid Ahmadieh, Robert A. Sisk, Salman Mirza, Samuray Tuncer, Amparo Navea Tejerina, Jorge Mataix, Francisco J. Ascaso, Jose S. Pulido, Rainer Guthoff, Winfried Goebel, Young Jung Roh, Alay S. Banker, Ronald C. Gentile, Isabel Alonso MartinezRodney Morris, Neeraj Panday, Park Jung Min, Emilie Mercé, Timothy Y.Y. Lai, Vicky Massoud, Nicola G. Ghazi

Ophthalmology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.2 at 12 months, and 5.5 at 24 months. CNV was subfoveal in 14 eyes, juxtafoveal in 5, extrafoveal in 5, and peripapillary in 2. By paired comparison, mean decrease from baseline was 119.7 microns at 6 months (n = 15; P = 0. 001), 105.3 microns at 1 year (n = 10; P = 0. 03), and 157.6 microns at 2 years (n = 7; P = 0. 08). BCVA improved by 3.3 lines at 6 months after therapy (n = 26; P < 0. 001), 2.8 lines (n = 20; P = 0. 01) at 1 year, and 3.1 lines (n = 13; P = 0. 049) at 2 years. We conclude that intravitreal anti-VEGF injections improve vision in majority of eyes with CNV from choroidal osteoma.

Original language	English (US)
Article number	210458
Journal	Journal of Ophthalmology
Volume	2014
DOIs	https://doi.org/10.1155/2014/210458
State	Published - 2014

ASJC Scopus subject areas

Ophthalmology

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Mansour, A. M., Arevalo, J. F., Al Kahtani, E., Zegarra, H., Abboud, E., Anand, R., Ahmadieh, H., Sisk, R. A., Mirza, S., Tuncer, S., Navea Tejerina, A., Mataix, J., Ascaso, F. J., Pulido, J. S., Guthoff, R., Goebel, W., Roh, Y. J., Banker, A. S., Gentile, R. C., ... Ghazi, N. G. (2014). Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma. Journal of Ophthalmology, 2014, Article 210458. https://doi.org/10.1155/2014/210458

Mansour, AM, Arevalo, JF, Al Kahtani, E, Zegarra, H, Abboud, E, Anand, R, Ahmadieh, H, Sisk, RA, Mirza, S, Tuncer, S, Navea Tejerina, A, Mataix, J, Ascaso, FJ, Pulido, JS, Guthoff, R, Goebel, W, Roh, YJ, Banker, AS, Gentile, RC, Martinez, IA, Morris, R, Panday, N, Min, PJ, Mercé, E, Lai, TYY, Massoud, V & Ghazi, NG 2014, 'Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma', Journal of Ophthalmology, vol. 2014, 210458. https://doi.org/10.1155/2014/210458

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title = "Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma",

abstract = "We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.2 at 12 months, and 5.5 at 24 months. CNV was subfoveal in 14 eyes, juxtafoveal in 5, extrafoveal in 5, and peripapillary in 2. By paired comparison, mean decrease from baseline was 119.7 microns at 6 months (n = 15; P = 0. 001), 105.3 microns at 1 year (n = 10; P = 0. 03), and 157.6 microns at 2 years (n = 7; P = 0. 08). BCVA improved by 3.3 lines at 6 months after therapy (n = 26; P < 0. 001), 2.8 lines (n = 20; P = 0. 01) at 1 year, and 3.1 lines (n = 13; P = 0. 049) at 2 years. We conclude that intravitreal anti-VEGF injections improve vision in majority of eyes with CNV from choroidal osteoma.",

author = "Mansour, {Ahmad M.} and Arevalo, {J. Fernando} and {Al Kahtani}, Eman and Hernando Zegarra and Emad Abboud and Rajiv Anand and Hamid Ahmadieh and Sisk, {Robert A.} and Salman Mirza and Samuray Tuncer and {Navea Tejerina}, Amparo and Jorge Mataix and Ascaso, {Francisco J.} and Pulido, {Jose S.} and Rainer Guthoff and Winfried Goebel and Roh, {Young Jung} and Banker, {Alay S.} and Gentile, {Ronald C.} and Martinez, {Isabel Alonso} and Rodney Morris and Neeraj Panday and Min, {Park Jung} and Emilie Merc{\'e} and Lai, {Timothy Y.Y.} and Vicky Massoud and Ghazi, {Nicola G.}",

note = "Publisher Copyright: {\textcopyright} 2014 Ahmad M. Mansour et al.",

year = "2014",

doi = "10.1155/2014/210458",

language = "English (US)",

volume = "2014",

journal = "Journal of Ophthalmology",

issn = "2090-004X",

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TY - JOUR

T1 - Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma

AU - Mansour, Ahmad M.

AU - Arevalo, J. Fernando

AU - Al Kahtani, Eman

AU - Zegarra, Hernando

AU - Abboud, Emad

AU - Anand, Rajiv

AU - Ahmadieh, Hamid

AU - Sisk, Robert A.

AU - Mirza, Salman

AU - Tuncer, Samuray

AU - Navea Tejerina, Amparo

AU - Mataix, Jorge

AU - Ascaso, Francisco J.

AU - Pulido, Jose S.

AU - Guthoff, Rainer

AU - Goebel, Winfried

AU - Roh, Young Jung

AU - Banker, Alay S.

AU - Gentile, Ronald C.

AU - Martinez, Isabel Alonso

AU - Morris, Rodney

AU - Panday, Neeraj

AU - Min, Park Jung

AU - Mercé, Emilie

AU - Lai, Timothy Y.Y.

AU - Massoud, Vicky

AU - Ghazi, Nicola G.

PY - 2014

Y1 - 2014

N2 - We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.2 at 12 months, and 5.5 at 24 months. CNV was subfoveal in 14 eyes, juxtafoveal in 5, extrafoveal in 5, and peripapillary in 2. By paired comparison, mean decrease from baseline was 119.7 microns at 6 months (n = 15; P = 0. 001), 105.3 microns at 1 year (n = 10; P = 0. 03), and 157.6 microns at 2 years (n = 7; P = 0. 08). BCVA improved by 3.3 lines at 6 months after therapy (n = 26; P < 0. 001), 2.8 lines (n = 20; P = 0. 01) at 1 year, and 3.1 lines (n = 13; P = 0. 049) at 2 years. We conclude that intravitreal anti-VEGF injections improve vision in majority of eyes with CNV from choroidal osteoma.

AB - We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.2 at 12 months, and 5.5 at 24 months. CNV was subfoveal in 14 eyes, juxtafoveal in 5, extrafoveal in 5, and peripapillary in 2. By paired comparison, mean decrease from baseline was 119.7 microns at 6 months (n = 15; P = 0. 001), 105.3 microns at 1 year (n = 10; P = 0. 03), and 157.6 microns at 2 years (n = 7; P = 0. 08). BCVA improved by 3.3 lines at 6 months after therapy (n = 26; P < 0. 001), 2.8 lines (n = 20; P = 0. 01) at 1 year, and 3.1 lines (n = 13; P = 0. 049) at 2 years. We conclude that intravitreal anti-VEGF injections improve vision in majority of eyes with CNV from choroidal osteoma.

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DO - 10.1155/2014/210458

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VL - 2014

JO - Journal of Ophthalmology

JF - Journal of Ophthalmology

M1 - 210458

ER -

Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma

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