Role of hydrostatic and oncotic pressures in renal sodium reabsorption

F. G. Knox, J. I. Mertz, John C Jr. Burnett, A. Haramati

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Physical factors, and renal interstitial hydrostatic pressure in particular, have an important effect on sodium excretion by the kidney. Changes in hydrostatic and oncotic pressures in the peritubular microcirculation may have effects on proximal tubule reabsorption under some, but not all, circumstances. In regard to control of sodium excretion, the loop of Henle may be a particularly important segment which is sensitive to transepithelial hydrostatic pressure changes. There is little evidence to support an effect of physical factors on sodium reabsorption by the distal tubule. The collecting tubule may be another pressure-sensitive site; however, changes in sodium reabsorption by deep nephrons in the kidney may account for changes that have been attributed to the collecting duct. Changes in intrarenal pressure may be an important link in the regulation of sodium excretion, particularly in pathological circumstances, such as the exaggerated natriuresis of hypertension and the sodium retention seen in congestive heart failure.

Original languageEnglish (US)
Pages (from-to)491-500
Number of pages10
JournalCirculation Research
Volume52
Issue number5
StatePublished - 1983

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Hydrostatic Pressure
Sodium
Kidney
Loop of Henle
Pressure
Natriuresis
Nephrons
Microcirculation
Renal Reabsorption
Heart Failure
Hypertension

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Role of hydrostatic and oncotic pressures in renal sodium reabsorption. / Knox, F. G.; Mertz, J. I.; Burnett, John C Jr.; Haramati, A.

In: Circulation Research, Vol. 52, No. 5, 1983, p. 491-500.

Research output: Contribution to journalArticle

Knox, FG, Mertz, JI, Burnett, JCJ & Haramati, A 1983, 'Role of hydrostatic and oncotic pressures in renal sodium reabsorption', Circulation Research, vol. 52, no. 5, pp. 491-500.
Knox, F. G. ; Mertz, J. I. ; Burnett, John C Jr. ; Haramati, A. / Role of hydrostatic and oncotic pressures in renal sodium reabsorption. In: Circulation Research. 1983 ; Vol. 52, No. 5. pp. 491-500.
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