Role of Flow Cytometry in the Diagnosis and Prognosis of Plasma Cell Myeloma

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

This article provides an overview of the role of flow cytometry in the diagnosis and follow-up of plasma cell myeloma. A brief introduction to the general immunophenotypic features of normal and myeloma plasma cells is provided, followed by a discussion of technical issues as they relate to the application of flow cytometry in this entity. The prognostic and therapeutic utility of flow cytometric immunophenotyping in myeloma is also analyzed, with an emphasis on the growing role of minimal residual analysis as potential biomarker for evaluating treatment efficacy and for tailoring risk-adapted treatment, in prospective clinical trials.

Original languageEnglish (US)
Pages (from-to)101-116
Number of pages16
JournalSurgical Pathology Clinics
Volume9
Issue number1
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Keywords

  • Flow cytometry
  • MGUS
  • Minimal residual disease
  • Myeloma
  • Plasma cells

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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