TY - JOUR
T1 - Role of extracellular vesicles in liver diseases and their therapeutic potential
AU - Kostallari, Enis
AU - Valainathan, Shantha
AU - Biquard, Louise
AU - Shah, Vijay H.
AU - Rautou, Pierre Emmanuel
N1 - Funding Information:
This work was supported by the American Association for the Study of Liver Diseases (Pinnacle Research Award), Mayo Clinic Center for Cell Signaling in Gastroenterology (P30DK084567, Pilot and Feasibility award), Regenerative Medicine Minnesota (P008848105) to EK, and the “Institut National de la Santé et de la Recherche Médicale” (ATIP AVENIR), the “Agence Nationale pour la Recherche” (ANR-18-CE14-0006-01, RHU QUID-NASH, ANR-18-IDEX-0001) and “Émergence, Ville de Paris”, Fondation ARC (to PER).
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/8
Y1 - 2021/8
N2 - More than eight hundred million people worldwide have chronic liver disease, with two million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards cirrhosis, for which there doesn't exists any cure except liver transplantation. Better understanding of the mechanisms leading to cirrhosis and its complications is needed to develop effective therapies. Extracellular vesicles (EVs) are released by cells and are important for cell-to-cell communication. EVs have been reported to be involved in homeostasis maintenance, as well as in liver diseases. In this review, we present current knowledge on the role of EVs in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, alcohol-associated liver disease, chronic viral hepatitis, primary liver cancers, acute liver injury and liver regeneration. Moreover, therapeutic strategies involving EVs as targets or as tools to treat liver diseases are summarized.
AB - More than eight hundred million people worldwide have chronic liver disease, with two million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards cirrhosis, for which there doesn't exists any cure except liver transplantation. Better understanding of the mechanisms leading to cirrhosis and its complications is needed to develop effective therapies. Extracellular vesicles (EVs) are released by cells and are important for cell-to-cell communication. EVs have been reported to be involved in homeostasis maintenance, as well as in liver diseases. In this review, we present current knowledge on the role of EVs in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, alcohol-associated liver disease, chronic viral hepatitis, primary liver cancers, acute liver injury and liver regeneration. Moreover, therapeutic strategies involving EVs as targets or as tools to treat liver diseases are summarized.
KW - Cirrhosis
KW - Exosomes
KW - Fibrosis
KW - Microvesicles
KW - Portal hypertension
KW - Steatosis
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U2 - 10.1016/j.addr.2021.05.026
DO - 10.1016/j.addr.2021.05.026
M3 - Review article
C2 - 34087329
AN - SCOPUS:85108086676
SN - 0169-409X
VL - 175
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
M1 - 113816
ER -