Ruolo dell'aggiunta di olii di pesce alla dieta nella nefropatia IgA: Implicazioni meccanicistiche

Translated title of the contribution: Role of dietary fish oil supplementation in IgA nephropathy: Mechanistic implications

Joseph Peter Grande, J. V. Donadio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

IgA nephropathy (IgAN) is now recognized as the most common primary glomerulonephritis worldwide. Although the clinical course is variable, many patients develop slowly progressive renal disease, culminating in end-stage renal disease 10-20 years after diagnosis. Some recent randomized clinical trials have suggested that dietary fish oil supplementation may be a relatively safe long-term therapeutic option for preventing the development of progressive renal disease in patients with IgAN. However, other studies have failed to demonstrate a protective effect of dietary fish oil supplementation in treatment of IgAN. Although in vitro studies have provided a theoretical basis for the use of dietary fish oil supplementation, potential mechanisms underlying the protective effect of fish oil have not been well defined. In this overview, recent clinical and experimental data providing a basis for the use of dietary fish oil supplementation in treatment of IgAN and other progressive renal diseases are reviewed.

Original languageItalian
Pages (from-to)201-209
Number of pages9
JournalMinerva Urologica e Nefrologica
Volume53
Issue number4
StatePublished - Dec 2001

Fingerprint

Unsaturated Dietary Fats
Fish Oils
Immunoglobulin A
Kidney
Glomerulonephritis
Chronic Kidney Failure
Therapeutics
Randomized Controlled Trials

Keywords

  • 5,8,11,14,17 eicosapentaenoic acid
  • Decosahexaenoic acids
  • DHA
  • EPA
  • Fish oils
  • Fish oils, therapeutic use
  • Glomerulonephritis, IgA, diet therapy
  • Pharmacology

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Ruolo dell'aggiunta di olii di pesce alla dieta nella nefropatia IgA : Implicazioni meccanicistiche. / Grande, Joseph Peter; Donadio, J. V.

In: Minerva Urologica e Nefrologica, Vol. 53, No. 4, 12.2001, p. 201-209.

Research output: Contribution to journalArticle

@article{eb4d7c369b084298840f78551321ab92,
title = "Ruolo dell'aggiunta di olii di pesce alla dieta nella nefropatia IgA: Implicazioni meccanicistiche",
abstract = "IgA nephropathy (IgAN) is now recognized as the most common primary glomerulonephritis worldwide. Although the clinical course is variable, many patients develop slowly progressive renal disease, culminating in end-stage renal disease 10-20 years after diagnosis. Some recent randomized clinical trials have suggested that dietary fish oil supplementation may be a relatively safe long-term therapeutic option for preventing the development of progressive renal disease in patients with IgAN. However, other studies have failed to demonstrate a protective effect of dietary fish oil supplementation in treatment of IgAN. Although in vitro studies have provided a theoretical basis for the use of dietary fish oil supplementation, potential mechanisms underlying the protective effect of fish oil have not been well defined. In this overview, recent clinical and experimental data providing a basis for the use of dietary fish oil supplementation in treatment of IgAN and other progressive renal diseases are reviewed.",
keywords = "5,8,11,14,17 eicosapentaenoic acid, Decosahexaenoic acids, DHA, EPA, Fish oils, Fish oils, therapeutic use, Glomerulonephritis, IgA, diet therapy, Pharmacology",
author = "Grande, {Joseph Peter} and Donadio, {J. V.}",
year = "2001",
month = "12",
language = "Italian",
volume = "53",
pages = "201--209",
journal = "Minerva Urologica e Nefrologica",
issn = "0393-2249",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "4",

}

TY - JOUR

T1 - Ruolo dell'aggiunta di olii di pesce alla dieta nella nefropatia IgA

T2 - Implicazioni meccanicistiche

AU - Grande, Joseph Peter

AU - Donadio, J. V.

PY - 2001/12

Y1 - 2001/12

N2 - IgA nephropathy (IgAN) is now recognized as the most common primary glomerulonephritis worldwide. Although the clinical course is variable, many patients develop slowly progressive renal disease, culminating in end-stage renal disease 10-20 years after diagnosis. Some recent randomized clinical trials have suggested that dietary fish oil supplementation may be a relatively safe long-term therapeutic option for preventing the development of progressive renal disease in patients with IgAN. However, other studies have failed to demonstrate a protective effect of dietary fish oil supplementation in treatment of IgAN. Although in vitro studies have provided a theoretical basis for the use of dietary fish oil supplementation, potential mechanisms underlying the protective effect of fish oil have not been well defined. In this overview, recent clinical and experimental data providing a basis for the use of dietary fish oil supplementation in treatment of IgAN and other progressive renal diseases are reviewed.

AB - IgA nephropathy (IgAN) is now recognized as the most common primary glomerulonephritis worldwide. Although the clinical course is variable, many patients develop slowly progressive renal disease, culminating in end-stage renal disease 10-20 years after diagnosis. Some recent randomized clinical trials have suggested that dietary fish oil supplementation may be a relatively safe long-term therapeutic option for preventing the development of progressive renal disease in patients with IgAN. However, other studies have failed to demonstrate a protective effect of dietary fish oil supplementation in treatment of IgAN. Although in vitro studies have provided a theoretical basis for the use of dietary fish oil supplementation, potential mechanisms underlying the protective effect of fish oil have not been well defined. In this overview, recent clinical and experimental data providing a basis for the use of dietary fish oil supplementation in treatment of IgAN and other progressive renal diseases are reviewed.

KW - 5,8,11,14,17 eicosapentaenoic acid

KW - Decosahexaenoic acids

KW - DHA

KW - EPA

KW - Fish oils

KW - Fish oils, therapeutic use

KW - Glomerulonephritis, IgA, diet therapy

KW - Pharmacology

UR - http://www.scopus.com/inward/record.url?scp=0035722361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035722361&partnerID=8YFLogxK

M3 - Article

C2 - 11753248

AN - SCOPUS:0035722361

VL - 53

SP - 201

EP - 209

JO - Minerva Urologica e Nefrologica

JF - Minerva Urologica e Nefrologica

SN - 0393-2249

IS - 4

ER -