Role of cytokines in the pathogenesis of inflammatory bowel disease

Konstantinos A. Papadakis, Stephan R. Targan

Research output: Contribution to journalReview article

552 Scopus citations

Abstract

Recent advances in the drug treatment of inflammatory bowel disease (IBD) have paralleled our understanding of the pathophysiology of ulcerative colitis and Crohn's disease. Several proinflammatory and immune-regulatory cytokines are upregulated in the mucosa of patients with IBD, and differences and similarities in the cytokine profiles of ulcerative colitis and Crohn's disease have been elucidated. Several clinical trials involving a chimeric anti-TNF-α (tumor necrosis factor-α) antibody have shown marked clinical benefit in the majority of patients with Crohn's disease, verifying the importance of TNF-α in the pathogenesis of Crohn's disease. In preliminary studies, treatment with recombinant human interleukin-10 has been beneficial in Crohn's disease but not in ulcerative colitis. Future treatment of IBD may include combination or sequential cytokine and anticytokine administration in defined groups of patients based on their mucosal cytokine profiles.

Original languageEnglish (US)
Pages (from-to)289-298
Number of pages10
JournalAnnual Review of Medicine
Volume51
DOIs
StatePublished - May 3 2000

Keywords

  • Crohn's disease
  • Interleukin-10
  • Treatment
  • Tumor necrosis factor-α
  • Ulcerative colitis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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