Role of coagulation and fibrinolytic system in prostate cancer

Manish Kohli, Varsha Kaushal, Paulette Mehta

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Patients with prostate carcinoma paradoxically have both a hypercoagulable state and a bleeding diathesis. Hypercoagulability manifested by venous and arterial thrombosis has been documented in several large clinical trials. However, many investigators have reported a high risk of postoperative bleeding in prostate cancer patients. Disseminated intravascular coagulopathy has also been commonly noted at different clinical stages of this indolent cancer. In this article we review clinical, laboratory, and experimental evidence for abnormalities of various components of the coagulation and plasminogen pathways and analyze their contribution in prostate cancer growth, progression, and angiogenesis. Finally, we propose potential therapeutic antiangiogenic strategies in patients with prostate cancer.

Original languageEnglish (US)
Pages (from-to)301-308
Number of pages8
JournalSeminars in Thrombosis and Hemostasis
Volume29
Issue number3
DOIs
StatePublished - Jun 1 2003

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Keywords

  • Angiogenesis
  • Bleeding
  • Fibrinolysis
  • Hypercoagulability
  • Prostate cancer

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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