Role of coagulation and fibrinolytic system in prostate cancer

Manish Kohli, Varsha Kaushal, Paulette Mehta

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Patients with prostate carcinoma paradoxically have both a hypercoagulable state and a bleeding diathesis. Hypercoagulability manifested by venous and arterial thrombosis has been documented in several large clinical trials. However, many investigators have reported a high risk of postoperative bleeding in prostate cancer patients. Disseminated intravascular coagulopathy has also been commonly noted at different clinical stages of this indolent cancer. In this article we review clinical, laboratory, and experimental evidence for abnormalities of various components of the coagulation and plasminogen pathways and analyze their contribution in prostate cancer growth, progression, and angiogenesis. Finally, we propose potential therapeutic antiangiogenic strategies in patients with prostate cancer.

Original languageEnglish (US)
Pages (from-to)301-308
Number of pages8
JournalSeminars in Thrombosis and Hemostasis
Volume29
Issue number3
DOIs
StatePublished - Jun 2003
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Hemorrhage
Thrombophilia
Plasminogen
Disease Susceptibility
Venous Thrombosis
Prostate
Research Personnel
Clinical Trials
Carcinoma
Growth
Neoplasms
Therapeutics

Keywords

  • Angiogenesis
  • Bleeding
  • Fibrinolysis
  • Hypercoagulability
  • Prostate cancer

ASJC Scopus subject areas

  • Hematology

Cite this

Role of coagulation and fibrinolytic system in prostate cancer. / Kohli, Manish; Kaushal, Varsha; Mehta, Paulette.

In: Seminars in Thrombosis and Hemostasis, Vol. 29, No. 3, 06.2003, p. 301-308.

Research output: Contribution to journalArticle

Kohli, Manish ; Kaushal, Varsha ; Mehta, Paulette. / Role of coagulation and fibrinolytic system in prostate cancer. In: Seminars in Thrombosis and Hemostasis. 2003 ; Vol. 29, No. 3. pp. 301-308.
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