Role of ceramide in suramin-induced cancer cell death

Jagjit S. Gill, Anthony J. Windebank

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. Recent in vitro studies from our laboratory report a disruption in glycolipid metabolism and cell death in suramin-treated neurons. Evidence presented in this study proposes to consolidate the neurotoxic and cytotoxic effects of suramin. Electron microscopic studies, bis-benzimide staining and DNA gel electrophoresis of suramin and C2- ceramide treatment revealed apoptotic cells in human breast, prostate and rat neuron like cell lines. Apoptotic cell death was preceded by an elevation in intracellular ceramide.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalCancer Letters
Volume119
Issue number2
DOIs
StatePublished - Nov 11 1997

Keywords

  • Apoptosis-BODIPY ceramide
  • Breast
  • PC12
  • Prostate

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Role of ceramide in suramin-induced cancer cell death'. Together they form a unique fingerprint.

  • Cite this