Role of ceramide in suramin-induced cancer cell death

Jagjit S. Gill; Anthony J. Windebank

doi:10.1016/S0304-3835(97)00272-3

Role of ceramide in suramin-induced cancer cell death

Jagjit S. Gill, Anthony J. Windebank

Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. Recent in vitro studies from our laboratory report a disruption in glycolipid metabolism and cell death in suramin-treated neurons. Evidence presented in this study proposes to consolidate the neurotoxic and cytotoxic effects of suramin. Electron microscopic studies, bis-benzimide staining and DNA gel electrophoresis of suramin and C₂- ceramide treatment revealed apoptotic cells in human breast, prostate and rat neuron like cell lines. Apoptotic cell death was preceded by an elevation in intracellular ceramide.

Original language	English (US)
Pages (from-to)	169-176
Number of pages	8
Journal	Cancer Letters
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(97)00272-3
State	Published - Nov 11 1997

Keywords

Apoptosis-BODIPY ceramide
Breast
PC12
Prostate

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/S0304-3835(97)00272-3

Cite this

@article{5261305b451c4890b541a8c11df71faa,

title = "Role of ceramide in suramin-induced cancer cell death",

abstract = "Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. Recent in vitro studies from our laboratory report a disruption in glycolipid metabolism and cell death in suramin-treated neurons. Evidence presented in this study proposes to consolidate the neurotoxic and cytotoxic effects of suramin. Electron microscopic studies, bis-benzimide staining and DNA gel electrophoresis of suramin and C2- ceramide treatment revealed apoptotic cells in human breast, prostate and rat neuron like cell lines. Apoptotic cell death was preceded by an elevation in intracellular ceramide.",

keywords = "Apoptosis-BODIPY ceramide, Breast, PC12, Prostate",

author = "Gill, {Jagjit S.} and Windebank, {Anthony J.}",

year = "1997",

month = nov,

day = "11",

doi = "10.1016/S0304-3835(97)00272-3",

language = "English (US)",

volume = "119",

pages = "169--176",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Role of ceramide in suramin-induced cancer cell death

AU - Gill, Jagjit S.

AU - Windebank, Anthony J.

PY - 1997/11/11

Y1 - 1997/11/11

N2 - Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. Recent in vitro studies from our laboratory report a disruption in glycolipid metabolism and cell death in suramin-treated neurons. Evidence presented in this study proposes to consolidate the neurotoxic and cytotoxic effects of suramin. Electron microscopic studies, bis-benzimide staining and DNA gel electrophoresis of suramin and C2- ceramide treatment revealed apoptotic cells in human breast, prostate and rat neuron like cell lines. Apoptotic cell death was preceded by an elevation in intracellular ceramide.

AB - Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. Recent in vitro studies from our laboratory report a disruption in glycolipid metabolism and cell death in suramin-treated neurons. Evidence presented in this study proposes to consolidate the neurotoxic and cytotoxic effects of suramin. Electron microscopic studies, bis-benzimide staining and DNA gel electrophoresis of suramin and C2- ceramide treatment revealed apoptotic cells in human breast, prostate and rat neuron like cell lines. Apoptotic cell death was preceded by an elevation in intracellular ceramide.

KW - Apoptosis-BODIPY ceramide

KW - Breast

KW - PC12

KW - Prostate

UR - http://www.scopus.com/inward/record.url?scp=0030715241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030715241&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(97)00272-3

DO - 10.1016/S0304-3835(97)00272-3

M3 - Article

C2 - 9570368

AN - SCOPUS:0030715241

SN - 0304-3835

VL - 119

SP - 169

EP - 176

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Role of ceramide in suramin-induced cancer cell death

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this