Role of caveolae in the airway

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Caveolae are flask-shaped invaginations of the plasma membrane that are rich in lipids and serve as microdomains to facilitate interactions between proteins at the membrane as well as intracellular components, thus modulating signal transduction, protein and lipid transport, and other processes. Constituent caveolar proteins such as caveolins and cavins also have scaffolding domains that anchor and regulate protein function. There is now evidence that caveolae and their constituent proteins are present in airway smooth muscle in a variety of species. Caveolae in airway cells contain or interact with molecules such as receptors, ion channels, and regulatory proteins that are key to the roles of airway epithelium and smooth muscle in regulating airway structure and function. Furthermore, caveolar protein expression and regulation appear to be important in mediating and modulating the effects of inflammation on the airway, thereby contributing to the pathophysiology of diseases such as asthma.

Original languageEnglish (US)
Title of host publicationCalcium Signaling In Airway Smooth Muscle Cells
PublisherSpringer International Publishing
Pages235-246
Number of pages12
Volume9783319013121
ISBN (Print)9783319013121, 3319013114, 9783319013114
DOIs
StatePublished - Nov 1 2013

Fingerprint

Caveolae
Proteins
Smooth Muscle
Caveolins
Lipids
Muscle
Protein Transport
Ion Channels
Signal transduction
Signal Transduction
Membrane Proteins
Asthma
Epithelium
Cell membranes
Cell Membrane
Anchors
Inflammation
Membranes
Molecules

Keywords

  • Airway
  • Caveolae
  • Caveolin
  • Cavin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pabelick, C. M., Singh, B. B., & Prakash, Y. S. (2013). Role of caveolae in the airway. In Calcium Signaling In Airway Smooth Muscle Cells (Vol. 9783319013121, pp. 235-246). Springer International Publishing. https://doi.org/10.1007/978-3-319-01312-1_12

Role of caveolae in the airway. / Pabelick, Christina M; Singh, Brij B.; Prakash, Y.s.

Calcium Signaling In Airway Smooth Muscle Cells. Vol. 9783319013121 Springer International Publishing, 2013. p. 235-246.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pabelick, CM, Singh, BB & Prakash, YS 2013, Role of caveolae in the airway. in Calcium Signaling In Airway Smooth Muscle Cells. vol. 9783319013121, Springer International Publishing, pp. 235-246. https://doi.org/10.1007/978-3-319-01312-1_12
Pabelick CM, Singh BB, Prakash YS. Role of caveolae in the airway. In Calcium Signaling In Airway Smooth Muscle Cells. Vol. 9783319013121. Springer International Publishing. 2013. p. 235-246 https://doi.org/10.1007/978-3-319-01312-1_12
Pabelick, Christina M ; Singh, Brij B. ; Prakash, Y.s. / Role of caveolae in the airway. Calcium Signaling In Airway Smooth Muscle Cells. Vol. 9783319013121 Springer International Publishing, 2013. pp. 235-246
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