Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy.

Niti R. Aggarwal, Matthew W. Martinez, Bernard J. Gersh, Panithaya Chareonthaitawee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cardiac resynchronization has emerged as a highly effective therapy for heart failure. However, up to 40% of patients do not benefit from this treatment. In this Review, we discuss the potential role of MRI and nuclear molecular imaging in providing additional insights into the response to cardiac resynchronization therapy. Variables with potential prognostic and therapeutic values include the evaluation of cardiac dyssynchrony, scar, cardiac sympathetic function, myocardial blood flow, myocardial glucose and oxidative metabolism. Other molecular targets to characterize apoptosis, fatty acid metabolism, angiogenesis and angiotensin-converting enzyme activity will also be described. The potential use of these techniques in identifying and measuring responses to cardiac resynchronization therapy and future areas of research will be explored.

Original languageEnglish (US)
Pages (from-to)759-770
Number of pages12
JournalNature reviews. Cardiology
Volume6
Issue number12
StatePublished - Dec 2009

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Cardiac Resynchronization Therapy
Molecular Imaging
Peptidyl-Dipeptidase A
Cicatrix
Fatty Acids
Therapeutics
Heart Failure
Apoptosis
Glucose
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Aggarwal, N. R., Martinez, M. W., Gersh, B. J., & Chareonthaitawee, P. (2009). Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy. Nature reviews. Cardiology, 6(12), 759-770.

Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy. / Aggarwal, Niti R.; Martinez, Matthew W.; Gersh, Bernard J.; Chareonthaitawee, Panithaya.

In: Nature reviews. Cardiology, Vol. 6, No. 12, 12.2009, p. 759-770.

Research output: Contribution to journalArticle

Aggarwal, NR, Martinez, MW, Gersh, BJ & Chareonthaitawee, P 2009, 'Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy.', Nature reviews. Cardiology, vol. 6, no. 12, pp. 759-770.
Aggarwal NR, Martinez MW, Gersh BJ, Chareonthaitawee P. Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy. Nature reviews. Cardiology. 2009 Dec;6(12):759-770.
Aggarwal, Niti R. ; Martinez, Matthew W. ; Gersh, Bernard J. ; Chareonthaitawee, Panithaya. / Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy. In: Nature reviews. Cardiology. 2009 ; Vol. 6, No. 12. pp. 759-770.
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