TY - JOUR
T1 - Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy
AU - Aggarwal, Niti R.
AU - Martinez, Matthew W.
AU - Gersh, Bernard J.
AU - Chareonthaitawee, Panithaya
N1 - Publisher Copyright:
© 2009 Macmillan Publishers Limited.
PY - 2009/12/4
Y1 - 2009/12/4
N2 - Cardiac resynchronization has emerged as a highly effective therapy for heart failure. However, up to 40% of patients do not benefit from this treatment. In this Review, we discuss the potential role of MRI and nuclear molecular imaging in providing additional insights into the response to cardiac resynchronization therapy. Variables with potential prognostic and therapeutic values include the evaluation of cardiac dyssynchrony, scar, cardiac sympathetic function, myocardial blood flow, myocardial glucose and oxidative metabolism. Other molecular targets to characterize apoptosis, fatty acid metabolism, angiogenesis and angiotensin-converting enzyme activity will also be described. The potential use of these techniques in identifying and measuring responses to cardiac resynchronization therapy and future areas of research will be explored.
AB - Cardiac resynchronization has emerged as a highly effective therapy for heart failure. However, up to 40% of patients do not benefit from this treatment. In this Review, we discuss the potential role of MRI and nuclear molecular imaging in providing additional insights into the response to cardiac resynchronization therapy. Variables with potential prognostic and therapeutic values include the evaluation of cardiac dyssynchrony, scar, cardiac sympathetic function, myocardial blood flow, myocardial glucose and oxidative metabolism. Other molecular targets to characterize apoptosis, fatty acid metabolism, angiogenesis and angiotensin-converting enzyme activity will also be described. The potential use of these techniques in identifying and measuring responses to cardiac resynchronization therapy and future areas of research will be explored.
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U2 - 10.1038/nrcardio.2009.189
DO - 10.1038/nrcardio.2009.189
M3 - Review article
C2 - 19884903
AN - SCOPUS:75549090320
SN - 1759-5002
VL - 6
SP - 759
EP - 770
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 12
ER -