Role of calcium ions in the stimulatory actions of luteinizing hormone in isolated ovarian cells: Studies with divalent-cation ionophores

Johannes D Veldhuis, Patricia A. Klase

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The divalent-cation ionophores A23187 and ionomycin exert dose-dependent suppressive effects on the stimulatory actions of luteinizing hormone in ovarian cells invitro. Micromolar concentrations of both A23187 and ionomycin can inhibit the production of progesterone and the stimulation of ornithine decarboxylase activity. Inhibitory concentrations of these ionophores deplete total cell content of calcium, and also seem to suppress protein synthesis.

Original languageEnglish (US)
Pages (from-to)603-610
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume104
Issue number2
DOIs
StatePublished - Jan 29 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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