Role of BMI in the association of the TCF7L2 rs7903146 variant with coronary heart disease: The atherosclerosis risk in communities (ARIC) study

Anna M. Kucharska-Newton, Keri L. Monda, Suzette J Bielinski, Eric Boerwinkle, Thomas D. Rea, Wayne D. Rosamond, James S. Pankow, Anna Köttgen, Gerardo Heiss, Kari E. North

Research output: Contribution to journalArticle

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Abstract

We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort. Cox proportional hazard regression analyses were performed using a general model, with the major homozygote as the reference category. For 9,865 whites, a significant increase in the risk of CHD was seen only among lean (BMI <25 kg/ m 2) individuals homozygous for the T allele of the TCF7L2 rs7903146 gene risk variant (hazard ratio 1.42; 95% CI 1.03,1.97; P=.01). No association was found among 3,631 blacks, regardless of BMI status. An attenuated hazard ratio was observed among the nondiabetic ARIC cohort members. This study suggests that body mass modifies the association of the TCF7L2 rs7903146 T allele with CHD risk.

Original languageEnglish (US)
Article number651903
JournalJournal of Obesity
Volume2010
DOIs
StatePublished - 2010

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Coronary Disease
Atherosclerosis
Alleles
Homozygote
Type 2 Diabetes Mellitus
Genes
Cohort Studies
Regression Analysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Role of BMI in the association of the TCF7L2 rs7903146 variant with coronary heart disease : The atherosclerosis risk in communities (ARIC) study. / Kucharska-Newton, Anna M.; Monda, Keri L.; Bielinski, Suzette J; Boerwinkle, Eric; Rea, Thomas D.; Rosamond, Wayne D.; Pankow, James S.; Köttgen, Anna; Heiss, Gerardo; North, Kari E.

In: Journal of Obesity, Vol. 2010, 651903, 2010.

Research output: Contribution to journalArticle

Kucharska-Newton, AM, Monda, KL, Bielinski, SJ, Boerwinkle, E, Rea, TD, Rosamond, WD, Pankow, JS, Köttgen, A, Heiss, G & North, KE 2010, 'Role of BMI in the association of the TCF7L2 rs7903146 variant with coronary heart disease: The atherosclerosis risk in communities (ARIC) study', Journal of Obesity, vol. 2010, 651903. https://doi.org/10.1155/2010/651903
Kucharska-Newton, Anna M. ; Monda, Keri L. ; Bielinski, Suzette J ; Boerwinkle, Eric ; Rea, Thomas D. ; Rosamond, Wayne D. ; Pankow, James S. ; Köttgen, Anna ; Heiss, Gerardo ; North, Kari E. / Role of BMI in the association of the TCF7L2 rs7903146 variant with coronary heart disease : The atherosclerosis risk in communities (ARIC) study. In: Journal of Obesity. 2010 ; Vol. 2010.
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abstract = "We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort. Cox proportional hazard regression analyses were performed using a general model, with the major homozygote as the reference category. For 9,865 whites, a significant increase in the risk of CHD was seen only among lean (BMI <25 kg/ m 2) individuals homozygous for the T allele of the TCF7L2 rs7903146 gene risk variant (hazard ratio 1.42; 95{\%} CI 1.03,1.97; P=.01). No association was found among 3,631 blacks, regardless of BMI status. An attenuated hazard ratio was observed among the nondiabetic ARIC cohort members. This study suggests that body mass modifies the association of the TCF7L2 rs7903146 T allele with CHD risk.",
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