Role of Bcl-2 in endometrioid corpus cancer: An experimental study

Andrea Mariani, Thomas J. Sebo, William A. Cliby, Gary L. Keeney, Darren L. Riehle, Timothy G. Lesnick, Karl C. Podratz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Bcl-2 expression appears to be under hormonal control in normal endometrium and to correlate with hormone receptor status in endometrial cancer. The aim of this study was to assess bcl-2 expression in endometrial cancer. Materials and Methods: Hysterectomy specimens from 125 patients with endometrial cancer were stained for bcl-2. Estrogen receptor (ER) and progesterone receptor (PR) levels were quantified with a dextran-coated charcoal assay. Results: Bcl-2 expression correlated significantly with endometrioid histology and high levels of ER and PR (p<0.05). For the entire population, bcl-2 expression was not significantly associated with the presence of extrauterine disease. However, when only patients with grade 1 or 2 endometrioid histology were considered, tumors with bcl-2 expression were significantly (p<0.05) more likely to present with extrauterine disease than those not expressing bcl-2. Conclusion: Bcl-2-mediated inhibition of apoptosis may be important in the acquisition of molecular alterations and development of metastases in a subset of hormone-dependent endometrial cancers.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalAnticancer research
Volume26
Issue number2 A
StatePublished - Mar 1 2006

Keywords

  • Bcl-2
  • Carcinogenesis
  • Endometrioid corpus cancer
  • Estrogen receptors
  • Histological subtype
  • Progesterone receptors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Mariani, A., Sebo, T. J., Cliby, W. A., Keeney, G. L., Riehle, D. L., Lesnick, T. G., & Podratz, K. C. (2006). Role of Bcl-2 in endometrioid corpus cancer: An experimental study. Anticancer research, 26(2 A), 823-827.