Role of Bcl-2 in endometrioid corpus cancer: An experimental study

Andrea Mariani, Thomas J. Sebo, William Arthur Cliby, Gary Keeney, Darren L. Riehle, Timothy G. Lesnick, Karl C. Podratz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Bcl-2 expression appears to be under hormonal control in normal endometrium and to correlate with hormone receptor status in endometrial cancer. The aim of this study was to assess bcl-2 expression in endometrial cancer. Materials and Methods: Hysterectomy specimens from 125 patients with endometrial cancer were stained for bcl-2. Estrogen receptor (ER) and progesterone receptor (PR) levels were quantified with a dextran-coated charcoal assay. Results: Bcl-2 expression correlated significantly with endometrioid histology and high levels of ER and PR (p<0.05). For the entire population, bcl-2 expression was not significantly associated with the presence of extrauterine disease. However, when only patients with grade 1 or 2 endometrioid histology were considered, tumors with bcl-2 expression were significantly (p<0.05) more likely to present with extrauterine disease than those not expressing bcl-2. Conclusion: Bcl-2-mediated inhibition of apoptosis may be important in the acquisition of molecular alterations and development of metastases in a subset of hormone-dependent endometrial cancers.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalAnticancer Research
Volume26
Issue number2 A
StatePublished - Mar 2006

Fingerprint

Endometrial Neoplasms
Progesterone Receptors
Estrogen Receptors
Neoplasms
Histology
Hormones
Charcoal
Endometrium
Dextrans
Hysterectomy
Apoptosis
Neoplasm Metastasis
Population

Keywords

  • Bcl-2
  • Carcinogenesis
  • Endometrioid corpus cancer
  • Estrogen receptors
  • Histological subtype
  • Progesterone receptors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mariani, A., Sebo, T. J., Cliby, W. A., Keeney, G., Riehle, D. L., Lesnick, T. G., & Podratz, K. C. (2006). Role of Bcl-2 in endometrioid corpus cancer: An experimental study. Anticancer Research, 26(2 A), 823-827.

Role of Bcl-2 in endometrioid corpus cancer : An experimental study. / Mariani, Andrea; Sebo, Thomas J.; Cliby, William Arthur; Keeney, Gary; Riehle, Darren L.; Lesnick, Timothy G.; Podratz, Karl C.

In: Anticancer Research, Vol. 26, No. 2 A, 03.2006, p. 823-827.

Research output: Contribution to journalArticle

Mariani, A, Sebo, TJ, Cliby, WA, Keeney, G, Riehle, DL, Lesnick, TG & Podratz, KC 2006, 'Role of Bcl-2 in endometrioid corpus cancer: An experimental study', Anticancer Research, vol. 26, no. 2 A, pp. 823-827.
Mariani A, Sebo TJ, Cliby WA, Keeney G, Riehle DL, Lesnick TG et al. Role of Bcl-2 in endometrioid corpus cancer: An experimental study. Anticancer Research. 2006 Mar;26(2 A):823-827.
Mariani, Andrea ; Sebo, Thomas J. ; Cliby, William Arthur ; Keeney, Gary ; Riehle, Darren L. ; Lesnick, Timothy G. ; Podratz, Karl C. / Role of Bcl-2 in endometrioid corpus cancer : An experimental study. In: Anticancer Research. 2006 ; Vol. 26, No. 2 A. pp. 823-827.
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