Role of autologous stem cell transplantation in multiple myeloma

Research output: Contribution to journalReview article

Abstract

High-dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown to improve survival in patients with multiple myeloma in randomized trials and is the standard of care for eligible patients. Recent randomized trials suggest a survival benefit with tandem ASCT, notably for patients failing to achieve a very good response to initial transplantation. Other randomized trials, as well as smaller phase II trials and retrospective studies, have allowed us to improve the process of ASCT in terms of the stem cell collection, conditioning regimens, and extension of the therapy to a wider patient population. The introduction of thalidomide, lenalidomide, and bortezomib have changed the paradigm for treatment of myeloma and significantly improved the outcome for these patients. The role of ASCT will clearly be redefined in the coming years with improvements in other therapies.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalCurrent Hematologic Malignancy Reports
Volume2
Issue number2
DOIs
StatePublished - Apr 1 2007

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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