Role of aggressive surgical cytoreduction in advanced ovarian cancer

Suk Joon Chang, Robert E. Bristow, Dennis S. Chi, William A. Cliby

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Ovarian cancer is the eighth most frequent cancer in women and is the most lethal gynecologic malignancy worldwide. The majority of ovarian cancer patients are newly diagnosed presenting with advanced-stage disease. Primary cytoreductive surgery and adjuvant taxane- and platinum-based combination chemotherapy are the standard treatment for advanced ovarian cancer. A number of studies have consistently shown that successful cytoreductive surgery and the resultant minimal residual disease are significantly associated with survival in patients with this disease. Much has been written and even more debated regarding the competing perspectives of biology of ovarian cancer versus the value of aggressive surgical resection. This review will focus on the current evidences and outcomes supporting the positive impact of aggressive surgical effort on survival in the primary management of ovarian cancer.

Original languageEnglish (US)
Pages (from-to)336-342
Number of pages7
JournalJournal of Gynecologic Oncology
Volume26
Issue number4
DOIs
StatePublished - Oct 2015

Keywords

  • Cytoreduction surgical procedures
  • Neoplasm
  • Ovarian neoplasms
  • Residual

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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