Role for the endogenous natriuretic peptide system in the control of basal coronary vascular tone in dogs

Thanom Supaporn, Paul W. Wennberg, Chi Ming Wei, Masahiko Kinoshita, Yuzuru Matsuda, John C Jr. Burnett

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

1. While the natriuretic peptides (atrial, brain and C-type) mediate potent endothelium-independent vasorelaxing actions in vitro, the role of the endogenous natriuretic peptide system in vascular regulation in vivo remains unclear. 2. HS-142-1 is a novel natriuretic peptide receptor antagonist derived;from a fungus named Aureobasidium sp, which selectively blocks particulate guanylate cyclase-linked natriuretic peptide A and B receptors that bind atrial, brain and C-type natriuretic peptide, and thus attenuates the generation of cGMP. 3. To characterize the vascular actions of the endogenous natriuretic peptide system in the control of basal coronary and systemic haemodynamics, six normal male mongrel anaesthetized dogs were studied while a second group of five dogs served as a control. HS-142-1 was given as an intravenous bolus at 3 mg/kg and was studied over five 20 min periods. 4. No significant difference after HS-142-1 was observed in mean arterial pressure, heart rate, cardiac output, right atrial pressure, pulmonary capillary wedge pressure or systemic vascular resistance compared with control. In contrast, a significant increase in coronary vascular resistance and decrease in coronary blood flow were observed which were different from the baseline values and the responses of the control group. 5. These studies demonstrate that HS-142-1 produces vasoconstriction in the coronary circulation. We conclude that the endogenous natriuretic peptide system, which is of cardiac and endothelial cell origin, is an important regulator of basal coronary vascular tone.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalClinical Science
Volume90
Issue number5
StatePublished - 1996

Fingerprint

Natriuretic Peptides
Blood Vessels
Dogs
Brain Natriuretic Peptide
Vascular Resistance
C-Type Natriuretic Peptide
Coronary Circulation
Pulmonary Wedge Pressure
Atrial Pressure
Peptide Receptors
Guanylate Cyclase
Atrial Natriuretic Factor
Vasoconstriction
Cardiac Output
Endothelium
Arterial Pressure
Fungi
Endothelial Cells
Heart Rate
Hemodynamics

Keywords

  • Coronary blood flow
  • Guanylyl cyclase
  • Natriuretic peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Supaporn, T., Wennberg, P. W., Wei, C. M., Kinoshita, M., Matsuda, Y., & Burnett, J. C. J. (1996). Role for the endogenous natriuretic peptide system in the control of basal coronary vascular tone in dogs. Clinical Science, 90(5), 357-362.

Role for the endogenous natriuretic peptide system in the control of basal coronary vascular tone in dogs. / Supaporn, Thanom; Wennberg, Paul W.; Wei, Chi Ming; Kinoshita, Masahiko; Matsuda, Yuzuru; Burnett, John C Jr.

In: Clinical Science, Vol. 90, No. 5, 1996, p. 357-362.

Research output: Contribution to journalArticle

Supaporn, T, Wennberg, PW, Wei, CM, Kinoshita, M, Matsuda, Y & Burnett, JCJ 1996, 'Role for the endogenous natriuretic peptide system in the control of basal coronary vascular tone in dogs', Clinical Science, vol. 90, no. 5, pp. 357-362.
Supaporn, Thanom ; Wennberg, Paul W. ; Wei, Chi Ming ; Kinoshita, Masahiko ; Matsuda, Yuzuru ; Burnett, John C Jr. / Role for the endogenous natriuretic peptide system in the control of basal coronary vascular tone in dogs. In: Clinical Science. 1996 ; Vol. 90, No. 5. pp. 357-362.
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