Role for adrenal venous sampling in primary aldosteronism

William Francis Young, Anthony W. Stanson, Geoffrey B. Thompson, Clive S. Grant, David R. Farley, Jon A. Van Heerden

Research output: Contribution to journalArticle

419 Citations (Scopus)

Abstract

The aim of this study was to determine the effect of adrenal venous sampling (AVS) on the management of patients with primary aldosteronism. From September 1990 through October 2003, 203 patients with primary aldosteronism (mean age, 53 years; range, 17-80; 163 men) were selected prospectively for AVS on the basis of degree of aldosterone excess, age, desire for surgical treatment, and computed tomographic (CT) findings. Both adrenal veins were catheterized in 194 patients (95.6%). Notable among the 110 patients (56.7%) with unilateral aldosterone hypersecretion were 24 (41.4%) of 58 patients with normal adrenal CT findings, 24 (51.1%) of 47 with unilateral micronodule (≤10 mm) apparent on CT (7 had unilateral aldosterone hypersecretion from the contralateral adrenal), 21 (65.6%) of 32 with unilateral macronodule (>10 mm) apparent on CT (1 had unilateral aldosterone hypersecretion from the contralateral adrenal), 16 (48.5%) of 33 with bilateral micronodules, and 2 (33%) of 6 with bilateral macronodules. On the basis of CT findings alone, 42 patients (21.7%) would have been incorrectly excluded as candidates for adrenalectomy, and 48 (24.7%) might have had unnecessary or inappropriate adrenalectomy. AVS is an essential diagnostic step in most patients to distinguish between unilateral and bilateral adrenal aldosterone hypersecretion.

Original languageEnglish (US)
Pages (from-to)1227-1235
Number of pages9
JournalSurgery
Volume136
Issue number6
DOIs
StatePublished - Dec 2004

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Hyperaldosteronism
Aldosterone
Adrenalectomy
Veins

ASJC Scopus subject areas

  • Surgery

Cite this

Young, W. F., Stanson, A. W., Thompson, G. B., Grant, C. S., Farley, D. R., & Van Heerden, J. A. (2004). Role for adrenal venous sampling in primary aldosteronism. Surgery, 136(6), 1227-1235. https://doi.org/10.1016/j.surg.2004.06.051

Role for adrenal venous sampling in primary aldosteronism. / Young, William Francis; Stanson, Anthony W.; Thompson, Geoffrey B.; Grant, Clive S.; Farley, David R.; Van Heerden, Jon A.

In: Surgery, Vol. 136, No. 6, 12.2004, p. 1227-1235.

Research output: Contribution to journalArticle

Young, WF, Stanson, AW, Thompson, GB, Grant, CS, Farley, DR & Van Heerden, JA 2004, 'Role for adrenal venous sampling in primary aldosteronism', Surgery, vol. 136, no. 6, pp. 1227-1235. https://doi.org/10.1016/j.surg.2004.06.051
Young WF, Stanson AW, Thompson GB, Grant CS, Farley DR, Van Heerden JA. Role for adrenal venous sampling in primary aldosteronism. Surgery. 2004 Dec;136(6):1227-1235. https://doi.org/10.1016/j.surg.2004.06.051
Young, William Francis ; Stanson, Anthony W. ; Thompson, Geoffrey B. ; Grant, Clive S. ; Farley, David R. ; Van Heerden, Jon A. / Role for adrenal venous sampling in primary aldosteronism. In: Surgery. 2004 ; Vol. 136, No. 6. pp. 1227-1235.
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