Rodent endosonography to monitor esophageal cancer

Navtej Singh Buttar, Maurits J. Wiersema, Kenneth Ke Ning Wang, Cathrine J. DeMars, Prasad G Iyer, Lori S. Lutzke

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Animal models of luminal cancers are important to understand and assess chemopreventive and chemotherapeutic interventions. However, the ability to assess tumor growth and response without animal sacrifice is limited. We assessed the ability of luminal sonography to assess the presence of tumor and its size in a surgical esophagojejunostomy model of esophageal cancer. Luminal sonography had a sensitivity of 88%, specificity of 100%, and accuracy of 93% in identifying the esophageal cancers. The tumor dimensions on luminal sonography were within 11% of autopsy measurements. Minimal tumor dimension was 2 mm and maximum 6.2 mm. The procedure was feasible without technical difficulty. In conclusion, rodent endosonography is a useful technique that can accurately determine the presence of tumors as well as their dimensions.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalInternational Journal of Gastrointestinal Cancer
Volume37
Issue number2-3
DOIs
StatePublished - Jun 2006

Fingerprint

Endosonography
Esophageal Neoplasms
Rodentia
Ultrasonography
Neoplasms
Anatomic Models
Autopsy
Animal Models
Sensitivity and Specificity
Growth

Keywords

  • Animal model
  • Barrett's esophagus
  • Chemoprevention
  • Esophageal cancer
  • Ultrasonography

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology
  • Oncology

Cite this

Rodent endosonography to monitor esophageal cancer. / Buttar, Navtej Singh; Wiersema, Maurits J.; Wang, Kenneth Ke Ning; DeMars, Cathrine J.; Iyer, Prasad G; Lutzke, Lori S.

In: International Journal of Gastrointestinal Cancer, Vol. 37, No. 2-3, 06.2006, p. 84-90.

Research output: Contribution to journalArticle

Buttar, Navtej Singh ; Wiersema, Maurits J. ; Wang, Kenneth Ke Ning ; DeMars, Cathrine J. ; Iyer, Prasad G ; Lutzke, Lori S. / Rodent endosonography to monitor esophageal cancer. In: International Journal of Gastrointestinal Cancer. 2006 ; Vol. 37, No. 2-3. pp. 84-90.
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AU - Iyer, Prasad G

AU - Lutzke, Lori S.

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