Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer

Paul A. Kay, Richard A. Robb, David G. Bostwick, Jon J. Camp

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

We have developed a technique to reconstruct 3-D microstructures from serial histologic section, and demonstrated the robustness of the method on microvessels associated with prostate cancer and bile ducts in liver specimens. The method is critically based on image coregistration techniques, particularly two dimensional surface matching between extracted image features. The reconstruction paradigm allows 3-D regions of information in several locations throughout a block of tissue to be obtained at different magnifications while maintaining proper spatial relationship to the original data. The reconstructed objects have a generally unmapped and unknown topography. Visualizing anatomic microstructures in 3-D and analyzing their topography will help physicians to better understand and correctly interpret changes in disease.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer Verlag
Pages129-134
Number of pages6
Volume1131
ISBN (Print)3540616497, 9783540616498
StatePublished - 1996
Event4th International Conference on Visualization in Biomedical Computing, VBC 1996 - Hamburg, Germany
Duration: Sep 22 1996Sep 25 1996

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1131
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other4th International Conference on Visualization in Biomedical Computing, VBC 1996
CountryGermany
CityHamburg
Period9/22/969/25/96

Fingerprint

Prostate Cancer
3D Reconstruction
Topography
3D
Microstructure
D region
Liver
Ducts
Tissue
Paradigm
Robustness
Unknown

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Kay, P. A., Robb, R. A., Bostwick, D. G., & Camp, J. J. (1996). Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 1131, pp. 129-134). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1131). Springer Verlag.

Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer. / Kay, Paul A.; Robb, Richard A.; Bostwick, David G.; Camp, Jon J.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 1131 Springer Verlag, 1996. p. 129-134 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1131).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kay, PA, Robb, RA, Bostwick, DG & Camp, JJ 1996, Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 1131, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 1131, Springer Verlag, pp. 129-134, 4th International Conference on Visualization in Biomedical Computing, VBC 1996, Hamburg, Germany, 9/22/96.
Kay PA, Robb RA, Bostwick DG, Camp JJ. Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 1131. Springer Verlag. 1996. p. 129-134. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
Kay, Paul A. ; Robb, Richard A. ; Bostwick, David G. ; Camp, Jon J. / Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 1131 Springer Verlag, 1996. pp. 129-134 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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