Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer

Paul A. Kay, Richard A. Robb, David G. Bostwick, Jon J. Camp

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

We have developed a technique to reconstruct 3-D microstructures from serial histologic section, and demonstrated the robustness of the method on microvessels associated with prostate cancer and bile ducts in liver specimens. The method is critically based on image coregistration techniques, particularly two dimensional surface matching between extracted image features. The reconstruction paradigm allows 3-D regions of information in several locations throughout a block of tissue to be obtained at different magnifications while maintaining proper spatial relationship to the original data. The reconstructed objects have a generally unmapped and unknown topography. Visualizing anatomic microstructures in 3-D and analyzing their topography will help physicians to better understand and correctly interpret changes in disease.

Original languageEnglish (US)
Title of host publicationVisualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings
EditorsKarl Heinz Hohne, Ron Kikinis
PublisherSpringer Verlag
Pages129-134
Number of pages6
ISBN (Print)3540616497, 9783540616498
DOIs
StatePublished - 1996
Event4th International Conference on Visualization in Biomedical Computing, VBC 1996 - Hamburg, Germany
Duration: Sep 22 1996Sep 25 1996

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1131
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other4th International Conference on Visualization in Biomedical Computing, VBC 1996
CountryGermany
CityHamburg
Period9/22/969/25/96

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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