RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation

Paloma Anguita-Alonso, Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Vittorio Saba, Giorgio Scalise, Milica Sevo, Marina Tuzova, Robin Patel, Naomi Balaban

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

Original languageEnglish (US)
Pages (from-to)2594-2596
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007

Fingerprint

Polymethyl Methacrylate
Biofilms
Staphylococcus aureus
Staphylococcus
Orthopedics
Anti-Bacterial Agents
Quorum Sensing
Methicillin-Resistant Staphylococcus aureus
Infection
RNAIII inhibiting peptide

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Anguita-Alonso, P., Giacometti, A., Cirioni, O., Ghiselli, R., Orlando, F., Saba, V., ... Balaban, N. (2007). RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation. Antimicrobial Agents and Chemotherapy, 51(7), 2594-2596. https://doi.org/10.1128/AAC.00580-06

RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation. / Anguita-Alonso, Paloma; Giacometti, Andrea; Cirioni, Oscar; Ghiselli, Roberto; Orlando, Fiorenza; Saba, Vittorio; Scalise, Giorgio; Sevo, Milica; Tuzova, Marina; Patel, Robin; Balaban, Naomi.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 7, 07.2007, p. 2594-2596.

Research output: Contribution to journalArticle

Anguita-Alonso, P, Giacometti, A, Cirioni, O, Ghiselli, R, Orlando, F, Saba, V, Scalise, G, Sevo, M, Tuzova, M, Patel, R & Balaban, N 2007, 'RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation', Antimicrobial Agents and Chemotherapy, vol. 51, no. 7, pp. 2594-2596. https://doi.org/10.1128/AAC.00580-06
Anguita-Alonso, Paloma ; Giacometti, Andrea ; Cirioni, Oscar ; Ghiselli, Roberto ; Orlando, Fiorenza ; Saba, Vittorio ; Scalise, Giorgio ; Sevo, Milica ; Tuzova, Marina ; Patel, Robin ; Balaban, Naomi. / RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 7. pp. 2594-2596.
@article{aa999cebfafc43f094e64696b01bdd51,
title = "RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation",
abstract = "Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.",
author = "Paloma Anguita-Alonso and Andrea Giacometti and Oscar Cirioni and Roberto Ghiselli and Fiorenza Orlando and Vittorio Saba and Giorgio Scalise and Milica Sevo and Marina Tuzova and Robin Patel and Naomi Balaban",
year = "2007",
month = "7",
doi = "10.1128/AAC.00580-06",
language = "English (US)",
volume = "51",
pages = "2594--2596",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "7",

}

TY - JOUR

T1 - RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation

AU - Anguita-Alonso, Paloma

AU - Giacometti, Andrea

AU - Cirioni, Oscar

AU - Ghiselli, Roberto

AU - Orlando, Fiorenza

AU - Saba, Vittorio

AU - Scalise, Giorgio

AU - Sevo, Milica

AU - Tuzova, Marina

AU - Patel, Robin

AU - Balaban, Naomi

PY - 2007/7

Y1 - 2007/7

N2 - Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

AB - Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

UR - http://www.scopus.com/inward/record.url?scp=34447264454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447264454&partnerID=8YFLogxK

U2 - 10.1128/AAC.00580-06

DO - 10.1128/AAC.00580-06

M3 - Article

C2 - 17116671

AN - SCOPUS:34447264454

VL - 51

SP - 2594

EP - 2596

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 7

ER -