TY - JOUR
T1 - RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation
AU - Anguita-Alonso, Paloma
AU - Giacometti, Andrea
AU - Cirioni, Oscar
AU - Ghiselli, Roberto
AU - Orlando, Fiorenza
AU - Saba, Vittorio
AU - Scalise, Giorgio
AU - Sevo, Milica
AU - Tuzova, Marina
AU - Patel, Robin
AU - Balaban, Naomi
N1 - Funding Information:
M. Serrano is thanked for producing Figure 1. The reviewers significantly helped to improve the paper. This study was funded by the PNP and the France-États-Unis fund from CNRS, the ANR and the European grant ORIGINS (MRTN-CT-2006-035519).
PY - 2007/7
Y1 - 2007/7
N2 - Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.
AB - Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.
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U2 - 10.1128/AAC.00580-06
DO - 10.1128/AAC.00580-06
M3 - Article
C2 - 17116671
AN - SCOPUS:34447264454
SN - 0066-4804
VL - 51
SP - 2594
EP - 2596
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 7
ER -