RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation

Paloma Anguita-Alonso, Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Vittorio Saba, Giorgio Scalise, Milica Sevo, Marina Tuzova, Robin Patel, Naomi Balaban

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

Original languageEnglish (US)
Pages (from-to)2594-2596
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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