RNA Therapeutics for Tissue Engineering

Elizabeth R. Balmayor, Christopher H Evans

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

RNA has several theoretical advantages as a therapeutic agent, but exploiting RNA in this fashion has faced several major hurdles. Not only is it unstable and difficult to deliver across hydrophobic cell membranes, but extraneous RNA also activates innate immune nucleic acid sensors, which makes it toxic and inflammatory.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
JournalTissue Engineering - Part A
Volume25
Issue number1-2
DOIs
StatePublished - Jan 1 2019

Keywords

  • DNA/RNA delivery
  • enabling technologies in tissue engineering
  • mesenchymal stem cells
  • messenger RNA
  • microRNA
  • RNA interference
  • small interfering RNA

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

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