RNA processing pathways in amyotrophic lateral sclerosis

Marka Van Blitterswijk, John E. Landers

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

RNA processing is a tightly regulated, highly complex pathway which includes RNA transcription, premRNA splicing, editing, transportation, translation, and degradation of RNA. Over the past few years, several RNA processing genes have been shown to be mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing may represent a common pathogenic mechanism involved in development of ALS. In this review, we will discuss six ALS-related, RNA processing genes including their discovery, function, and commonalities.

Original languageEnglish (US)
Pages (from-to)275-290
Number of pages16
JournalNeurogenetics
Volume11
Issue number3
DOIs
StatePublished - Jul 2010

Keywords

  • Amyotrophic lateral sclerosis
  • Mutation
  • RNA processing
  • Splicing
  • Transcription

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Cellular and Molecular Neuroscience

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