RNA interference in embryonic stem cells and the prospects for future therapies

A. Heidersbach, A. Gaspar-Maia, M. T. McManus, M. Ramalho-Santos

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

In 1998, two distinct and exciting scientific fields emerged which have profoundly shaped the current direction of biomedical research. The discovery of RNA interference (RNAi) and the derivation of human embryonic stem (ES) cells have yielded exciting new possibilities for researchers and clinicians alike. While fundamentally different, aspects from these two fields may be combined to yield extraordinary scientific and medical benefits. Here, we review the prospects of combining RNAi and ES cell manipulation for both basic research and future therapies, as well as current limitations and obstacles that need to be overcome.

Original languageEnglish (US)
Pages (from-to)478-486
Number of pages9
JournalGene Therapy
Volume13
Issue number6
DOIs
StatePublished - Mar 1 2006

Keywords

  • Cell-replacement therapy
  • Differentiation
  • ES cells
  • RNAi
  • miRNA
  • siRNA

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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