Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: A Children's Oncology Group Report

Stanton Goldman, Lynette Smith, Paul Galardy, Sherrie L. Perkins, John Kimble Frazer, Warren Sanger, James R. Anderson, Thomas G. Gross, Howard Weinstein, Lauren Harrison, Bruce Shiramizu, Matthew Barth, Mitchell S. Cairo

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Children and adolescents with Burkitt Lymphoma (BL) and combined central nervous system (CNS) and bone marrow involvement still have a poor prognosis with chemotherapy alone. We therefore investigated in children and adolescents with bone marrow (≥25% blasts) and/or CNS-positive Burkitt lymphoma the chemoimmunotherapy combination of rituximab (375 mg/m2) and the standard chemotherapy arm of our previously reported French-American-British (FAB) Lymphome Malins de Burkitt (LMB) 96 trial. Central pathological and cytogenetic characterization was also performed. There were 40 evaluable patients with Burkitt histology (25 with leukaemia and 15 with CNS disease ± leukaemia). The chemoimmunotherapy regimen was well tolerated. The incidence of grade III/IV mucositis during induction cycles with combined chemotherapy and rituximab was 31% and 26%, respectively. The 3-year event-free survival (EFS)/overall survival (OS) was 90% (95% confidence interval [CI], 76-96%) in the entire cohort and 93% (95% CI, 61-99%) in patients with CNS disease. Based on the results of this trial, an international randomized study of FAB/LMB 96 chemotherapy ± rituximab for high-risk patients is currently under investigation.

Original languageEnglish (US)
Pages (from-to)394-401
Number of pages8
JournalBritish journal of haematology
Volume167
Issue number3
DOIs
StatePublished - Nov 1 2014

Keywords

  • Burkitt leukaemia
  • Burkitt lymphoma
  • Chemotherapy
  • Children
  • Rituximab

ASJC Scopus subject areas

  • Hematology

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    Goldman, S., Smith, L., Galardy, P., Perkins, S. L., Frazer, J. K., Sanger, W., Anderson, J. R., Gross, T. G., Weinstein, H., Harrison, L., Shiramizu, B., Barth, M., & Cairo, M. S. (2014). Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: A Children's Oncology Group Report. British journal of haematology, 167(3), 394-401. https://doi.org/10.1111/bjh.13040