Rituximab for successful management of probable pediatric catastrophic antiphospholipid syndrome

Amulya A.Nageswara Rao, Grace M. Arteaga, Ann M. Reed, James M. Gloor, Vilmarie Rodriguez

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening condition characterized by small-vessel thrombi and a rapid onset of multiorgan system failure associated with systemic inflammatory response syndrome. Current treatment options include anticoagulants, corticosteroids, plasma exchange, and intravenous immunoglobulin, but these are not always effective. Rituximab, a chimeric anti-CD20 monoclonal antibody, may help eliminate autoreactive B cells and thus limit the rapid inflammatory process involved in CAPS. We describe the use of rituximab in the successful initial management of a probable case of pediatric CAPS.

Original languageEnglish (US)
Pages (from-to)536-538
Number of pages3
JournalPediatric Blood and Cancer
Volume52
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Catastrophic antiphospholipid syndrome
  • Lupus anticoagulant;rituximab; thrombosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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