Risk tables for parkinsonism and Parkinson's disease

Alexis Elbaz, James Howard Bower, Demetrius M. Maraganore, Shannon K. McDonnell, Brett J. Peterson, J. Eric Ahlskog, Daniel J Schaid, Walter A Rocca

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

We applied the incidence rates of parkinsonism and Parkinson's disease (PD) from Olmsted County, MN (1976-1990) to a hypothetical cohort undergoing the mortality rates observed in Minnesota, and computed the lifetime risk and the remaining lifetime risk of developing parkinsonism and PD. These risks were compared to cumulative incidences that do not take competing risks of death into account. The lifetime risk of developing parkinsonism from birth was 4.4% for men and 3.7% for women (ratio = 1.2). The corresponding risk of developing PD was 2.0% for men and 1.3% for women (ratio = 1.5). Because of the opposite effect of higher incidence and higher mortality rates in men, the lifetime risks were only slightly higher in men than in women. Lifetime cumulative incidences were consistently higher than lifetime risks; this difference was more pronounced in men and in older subjects. Lifetime risk estimates are useful in clinical practice, epidemiologic research, and public health.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalJournal of Clinical Epidemiology
Volume55
Issue number1
DOIs
StatePublished - 2002

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Parkinsonian Disorders
Parkinson Disease
Incidence
Mortality
Public Health
Parturition
Research

Keywords

  • Competing risks
  • Cumulative risk
  • Epidemiology
  • Lifetime risk
  • Parkinson's disease
  • Parkinsonism

ASJC Scopus subject areas

  • Medicine(all)
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Risk tables for parkinsonism and Parkinson's disease. / Elbaz, Alexis; Bower, James Howard; Maraganore, Demetrius M.; McDonnell, Shannon K.; Peterson, Brett J.; Ahlskog, J. Eric; Schaid, Daniel J; Rocca, Walter A.

In: Journal of Clinical Epidemiology, Vol. 55, No. 1, 2002, p. 25-31.

Research output: Contribution to journalArticle

Elbaz, Alexis ; Bower, James Howard ; Maraganore, Demetrius M. ; McDonnell, Shannon K. ; Peterson, Brett J. ; Ahlskog, J. Eric ; Schaid, Daniel J ; Rocca, Walter A. / Risk tables for parkinsonism and Parkinson's disease. In: Journal of Clinical Epidemiology. 2002 ; Vol. 55, No. 1. pp. 25-31.
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