Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer

Saurabh S. Mukewar, Ayush Sharma, Nissy Phillip, Ridhi Gupta, Anupama Aryal-Khanal, Nicolo de Pretis, Vincent Anani, Felicity T Enders, Joseph J. Larson, Naoki Takahashi, Michael J. Levy, Mark Topazian, Randall K. Pearson, Santhi Swaroop Vege, Suresh T Chari

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background & Aims: A diagnosis of pancreatic cancer in a first-degree relative increases an individuals’ risk of this cancer. However, it is not clear whether this cancer risk increases in individuals with pancreatic cystic lesions who have a first-degree relative with pancreatic cancer. The Fukuoka criteria are used to estimate risk of pancreatic cancer for patients with pancreatic cystic lesions: individuals with cysts with high risk or worrisome features (Fukuoka positive) have a higher risk of pancreatic cancer than individuals without these features (Fukuoka negative). We aimed to compare the risk of pancreatic cancer and surgery based on presence or absence of pancreatic cystic lesions and a first-degree relative with pancreatic cancer. Methods: We performed a retrospective study of patients seen at the Mayo Clinic in Rochester, Minnesota, from January 1, 2000, through December 31, 2012. We identified individuals with: pancreatic cystic lesions and first-degree relative with pancreatic cancer (group 1, n = 269), individuals with pancreatic cystic lesions but no first-degree relative with pancreatic cancer (group 2, n = 1195), and individuals without pancreatic cystic lesions but with a first-degree relative with pancreatic cancer (group 3, n = 720). We compared, among groups, as well among patients with cysts classified according to Fukuoka criteria, proportions of individuals who developed pancreatic cancer or underwent pancreatic surgery within a 5-year period. Results: A significantly higher proportion of individuals in group 1 developed pancreatic cancer during the 5-year period than in group 3 (6.64% vs 1.69%; P =.03); there was no significant difference between the percentage of individuals in group 1 vs group 2 who developed pancreatic cancer (6.64% vs 4.05%; P =.41). There was no significant difference in pancreatic cancer development among individuals with Fukuoka-positive cysts with vs without a family history of pancreatic cancer (P =.39). There was no significant difference in the proportion of patients in group 1 vs group 2 who underwent pancreatic surgery for their pancreatic cyst over the 5-year period (14.37% vs 11.80%; P =.59). Among patients with Fukuoka-negative cysts, a significantly higher proportion underwent surgery in group 1 than in group 2 (10.90% vs 5.90%; P =.03). However, among patients with Fukuoka-positive cysts, there was no difference in proportions of patients who underwent surgery between groups 1 and 2 (P =.66). Conclusions: In a retrospective study of patients with pancreatic cysts and/or cancer, we found that a family history of pancreatic cancer does not affect 5-year risk of pancreatic cancer in patients with pancreatic cystic lesions. Despite this, among patients with Fukuoka-negative cysts, a higher proportion of those with a family history of pancreatic cancer undergo surgery than patients without family history of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1123-1130.e1
JournalClinical Gastroenterology and Hepatology
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2018

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Pancreatic Cyst
Pancreatic Neoplasms
Cysts
Retrospective Studies

Keywords

  • Family History
  • First-Degree Relative
  • Pancreatic Surgery
  • Pancreatic Tumors

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Mukewar, S. S., Sharma, A., Phillip, N., Gupta, R., Aryal-Khanal, A., de Pretis, N., ... Chari, S. T. (2018). Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer. Clinical Gastroenterology and Hepatology, 16(7), 1123-1130.e1. https://doi.org/10.1016/j.cgh.2018.01.049

Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer. / Mukewar, Saurabh S.; Sharma, Ayush; Phillip, Nissy; Gupta, Ridhi; Aryal-Khanal, Anupama; de Pretis, Nicolo; Anani, Vincent; Enders, Felicity T; Larson, Joseph J.; Takahashi, Naoki; Levy, Michael J.; Topazian, Mark; Pearson, Randall K.; Vege, Santhi Swaroop; Chari, Suresh T.

In: Clinical Gastroenterology and Hepatology, Vol. 16, No. 7, 01.07.2018, p. 1123-1130.e1.

Research output: Contribution to journalArticle

Mukewar, SS, Sharma, A, Phillip, N, Gupta, R, Aryal-Khanal, A, de Pretis, N, Anani, V, Enders, FT, Larson, JJ, Takahashi, N, Levy, MJ, Topazian, M, Pearson, RK, Vege, SS & Chari, ST 2018, 'Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer', Clinical Gastroenterology and Hepatology, vol. 16, no. 7, pp. 1123-1130.e1. https://doi.org/10.1016/j.cgh.2018.01.049
Mukewar, Saurabh S. ; Sharma, Ayush ; Phillip, Nissy ; Gupta, Ridhi ; Aryal-Khanal, Anupama ; de Pretis, Nicolo ; Anani, Vincent ; Enders, Felicity T ; Larson, Joseph J. ; Takahashi, Naoki ; Levy, Michael J. ; Topazian, Mark ; Pearson, Randall K. ; Vege, Santhi Swaroop ; Chari, Suresh T. / Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer. In: Clinical Gastroenterology and Hepatology. 2018 ; Vol. 16, No. 7. pp. 1123-1130.e1.
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abstract = "Background & Aims: A diagnosis of pancreatic cancer in a first-degree relative increases an individuals’ risk of this cancer. However, it is not clear whether this cancer risk increases in individuals with pancreatic cystic lesions who have a first-degree relative with pancreatic cancer. The Fukuoka criteria are used to estimate risk of pancreatic cancer for patients with pancreatic cystic lesions: individuals with cysts with high risk or worrisome features (Fukuoka positive) have a higher risk of pancreatic cancer than individuals without these features (Fukuoka negative). We aimed to compare the risk of pancreatic cancer and surgery based on presence or absence of pancreatic cystic lesions and a first-degree relative with pancreatic cancer. Methods: We performed a retrospective study of patients seen at the Mayo Clinic in Rochester, Minnesota, from January 1, 2000, through December 31, 2012. We identified individuals with: pancreatic cystic lesions and first-degree relative with pancreatic cancer (group 1, n = 269), individuals with pancreatic cystic lesions but no first-degree relative with pancreatic cancer (group 2, n = 1195), and individuals without pancreatic cystic lesions but with a first-degree relative with pancreatic cancer (group 3, n = 720). We compared, among groups, as well among patients with cysts classified according to Fukuoka criteria, proportions of individuals who developed pancreatic cancer or underwent pancreatic surgery within a 5-year period. Results: A significantly higher proportion of individuals in group 1 developed pancreatic cancer during the 5-year period than in group 3 (6.64{\%} vs 1.69{\%}; P =.03); there was no significant difference between the percentage of individuals in group 1 vs group 2 who developed pancreatic cancer (6.64{\%} vs 4.05{\%}; P =.41). There was no significant difference in pancreatic cancer development among individuals with Fukuoka-positive cysts with vs without a family history of pancreatic cancer (P =.39). There was no significant difference in the proportion of patients in group 1 vs group 2 who underwent pancreatic surgery for their pancreatic cyst over the 5-year period (14.37{\%} vs 11.80{\%}; P =.59). Among patients with Fukuoka-negative cysts, a significantly higher proportion underwent surgery in group 1 than in group 2 (10.90{\%} vs 5.90{\%}; P =.03). However, among patients with Fukuoka-positive cysts, there was no difference in proportions of patients who underwent surgery between groups 1 and 2 (P =.66). Conclusions: In a retrospective study of patients with pancreatic cysts and/or cancer, we found that a family history of pancreatic cancer does not affect 5-year risk of pancreatic cancer in patients with pancreatic cystic lesions. Despite this, among patients with Fukuoka-negative cysts, a higher proportion of those with a family history of pancreatic cancer undergo surgery than patients without family history of pancreatic cancer.",
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author = "Mukewar, {Saurabh S.} and Ayush Sharma and Nissy Phillip and Ridhi Gupta and Anupama Aryal-Khanal and {de Pretis}, Nicolo and Vincent Anani and Enders, {Felicity T} and Larson, {Joseph J.} and Naoki Takahashi and Levy, {Michael J.} and Mark Topazian and Pearson, {Randall K.} and Vege, {Santhi Swaroop} and Chari, {Suresh T}",
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TY - JOUR

T1 - Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer

AU - Mukewar, Saurabh S.

AU - Sharma, Ayush

AU - Phillip, Nissy

AU - Gupta, Ridhi

AU - Aryal-Khanal, Anupama

AU - de Pretis, Nicolo

AU - Anani, Vincent

AU - Enders, Felicity T

AU - Larson, Joseph J.

AU - Takahashi, Naoki

AU - Levy, Michael J.

AU - Topazian, Mark

AU - Pearson, Randall K.

AU - Vege, Santhi Swaroop

AU - Chari, Suresh T

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background & Aims: A diagnosis of pancreatic cancer in a first-degree relative increases an individuals’ risk of this cancer. However, it is not clear whether this cancer risk increases in individuals with pancreatic cystic lesions who have a first-degree relative with pancreatic cancer. The Fukuoka criteria are used to estimate risk of pancreatic cancer for patients with pancreatic cystic lesions: individuals with cysts with high risk or worrisome features (Fukuoka positive) have a higher risk of pancreatic cancer than individuals without these features (Fukuoka negative). We aimed to compare the risk of pancreatic cancer and surgery based on presence or absence of pancreatic cystic lesions and a first-degree relative with pancreatic cancer. Methods: We performed a retrospective study of patients seen at the Mayo Clinic in Rochester, Minnesota, from January 1, 2000, through December 31, 2012. We identified individuals with: pancreatic cystic lesions and first-degree relative with pancreatic cancer (group 1, n = 269), individuals with pancreatic cystic lesions but no first-degree relative with pancreatic cancer (group 2, n = 1195), and individuals without pancreatic cystic lesions but with a first-degree relative with pancreatic cancer (group 3, n = 720). We compared, among groups, as well among patients with cysts classified according to Fukuoka criteria, proportions of individuals who developed pancreatic cancer or underwent pancreatic surgery within a 5-year period. Results: A significantly higher proportion of individuals in group 1 developed pancreatic cancer during the 5-year period than in group 3 (6.64% vs 1.69%; P =.03); there was no significant difference between the percentage of individuals in group 1 vs group 2 who developed pancreatic cancer (6.64% vs 4.05%; P =.41). There was no significant difference in pancreatic cancer development among individuals with Fukuoka-positive cysts with vs without a family history of pancreatic cancer (P =.39). There was no significant difference in the proportion of patients in group 1 vs group 2 who underwent pancreatic surgery for their pancreatic cyst over the 5-year period (14.37% vs 11.80%; P =.59). Among patients with Fukuoka-negative cysts, a significantly higher proportion underwent surgery in group 1 than in group 2 (10.90% vs 5.90%; P =.03). However, among patients with Fukuoka-positive cysts, there was no difference in proportions of patients who underwent surgery between groups 1 and 2 (P =.66). Conclusions: In a retrospective study of patients with pancreatic cysts and/or cancer, we found that a family history of pancreatic cancer does not affect 5-year risk of pancreatic cancer in patients with pancreatic cystic lesions. Despite this, among patients with Fukuoka-negative cysts, a higher proportion of those with a family history of pancreatic cancer undergo surgery than patients without family history of pancreatic cancer.

AB - Background & Aims: A diagnosis of pancreatic cancer in a first-degree relative increases an individuals’ risk of this cancer. However, it is not clear whether this cancer risk increases in individuals with pancreatic cystic lesions who have a first-degree relative with pancreatic cancer. The Fukuoka criteria are used to estimate risk of pancreatic cancer for patients with pancreatic cystic lesions: individuals with cysts with high risk or worrisome features (Fukuoka positive) have a higher risk of pancreatic cancer than individuals without these features (Fukuoka negative). We aimed to compare the risk of pancreatic cancer and surgery based on presence or absence of pancreatic cystic lesions and a first-degree relative with pancreatic cancer. Methods: We performed a retrospective study of patients seen at the Mayo Clinic in Rochester, Minnesota, from January 1, 2000, through December 31, 2012. We identified individuals with: pancreatic cystic lesions and first-degree relative with pancreatic cancer (group 1, n = 269), individuals with pancreatic cystic lesions but no first-degree relative with pancreatic cancer (group 2, n = 1195), and individuals without pancreatic cystic lesions but with a first-degree relative with pancreatic cancer (group 3, n = 720). We compared, among groups, as well among patients with cysts classified according to Fukuoka criteria, proportions of individuals who developed pancreatic cancer or underwent pancreatic surgery within a 5-year period. Results: A significantly higher proportion of individuals in group 1 developed pancreatic cancer during the 5-year period than in group 3 (6.64% vs 1.69%; P =.03); there was no significant difference between the percentage of individuals in group 1 vs group 2 who developed pancreatic cancer (6.64% vs 4.05%; P =.41). There was no significant difference in pancreatic cancer development among individuals with Fukuoka-positive cysts with vs without a family history of pancreatic cancer (P =.39). There was no significant difference in the proportion of patients in group 1 vs group 2 who underwent pancreatic surgery for their pancreatic cyst over the 5-year period (14.37% vs 11.80%; P =.59). Among patients with Fukuoka-negative cysts, a significantly higher proportion underwent surgery in group 1 than in group 2 (10.90% vs 5.90%; P =.03). However, among patients with Fukuoka-positive cysts, there was no difference in proportions of patients who underwent surgery between groups 1 and 2 (P =.66). Conclusions: In a retrospective study of patients with pancreatic cysts and/or cancer, we found that a family history of pancreatic cancer does not affect 5-year risk of pancreatic cancer in patients with pancreatic cystic lesions. Despite this, among patients with Fukuoka-negative cysts, a higher proportion of those with a family history of pancreatic cancer undergo surgery than patients without family history of pancreatic cancer.

KW - Family History

KW - First-Degree Relative

KW - Pancreatic Surgery

KW - Pancreatic Tumors

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