Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes

Deirdre A. Hill, Sophia S. Wang, James R Cerhan, Scott Davis, Wendy Cozen, Richard K. Severson, Patricia Hartge, Sholom Wacholder, Meredith Yeager, Stephen J. Chanock, Nathaniel Rothman

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Chromosomal translocations, insertions, and deletions are common early events in non-Hodgkin lymphoma (NHL) carcinogenesis, and implicated in their formation are endogenous processes involved in antigen-receptor diversification, such as V(D)J recombination. DNA repair genes respond to the double- and single-strand breaks induced by these processes and may influence NHL etiology. We examined 34 genetic variants in 19 genes within or related to 5 DNA repair pathways among 1172 cases and 982 matched controls who participated in a populationbased NHL study in Los Angeles, Seattle, Detroit, and Iowa from 1998 to 2000. Cases were more likely than controls to have the RAG1 820 R/R (odds ratio [OR] = 2.7; 95% confidence interval [CI] = 1.4 to 5.0) than Lys/Lys genotypes, with evidence of a gene dosage effect (P trend < .001), and less likely to have the LIG4 (DNA ligase IV) 9 Ile/Ile (OR = 0.5; 95% CI = 0.3 to 0.9) than T/T genotype (P trend = .03) in the nonhomologous end joining (NHEJ)/V(D)J pathway. These NHEJ/V(D)J-related gene variants represent promising candidates for further studies of NHL etiology and require replication in other studies.

Original languageEnglish (US)
Pages (from-to)3161-3167
Number of pages7
JournalBlood
Volume108
Issue number9
DOIs
StatePublished - Nov 1 2006

Fingerprint

DNA Repair
Non-Hodgkin's Lymphoma
Repair
Genes
DNA
Joining
Odds Ratio
Genotype
V(D)J Recombination
Confidence Intervals
DNA Ligases
Genetic Translocation
Antigen Receptors
Gene Dosage
Los Angeles
Carcinogenesis

ASJC Scopus subject areas

  • Hematology

Cite this

Hill, D. A., Wang, S. S., Cerhan, J. R., Davis, S., Cozen, W., Severson, R. K., ... Rothman, N. (2006). Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. Blood, 108(9), 3161-3167. https://doi.org/10.1182/blood-2005-01-026690

Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. / Hill, Deirdre A.; Wang, Sophia S.; Cerhan, James R; Davis, Scott; Cozen, Wendy; Severson, Richard K.; Hartge, Patricia; Wacholder, Sholom; Yeager, Meredith; Chanock, Stephen J.; Rothman, Nathaniel.

In: Blood, Vol. 108, No. 9, 01.11.2006, p. 3161-3167.

Research output: Contribution to journalArticle

Hill, DA, Wang, SS, Cerhan, JR, Davis, S, Cozen, W, Severson, RK, Hartge, P, Wacholder, S, Yeager, M, Chanock, SJ & Rothman, N 2006, 'Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes', Blood, vol. 108, no. 9, pp. 3161-3167. https://doi.org/10.1182/blood-2005-01-026690
Hill, Deirdre A. ; Wang, Sophia S. ; Cerhan, James R ; Davis, Scott ; Cozen, Wendy ; Severson, Richard K. ; Hartge, Patricia ; Wacholder, Sholom ; Yeager, Meredith ; Chanock, Stephen J. ; Rothman, Nathaniel. / Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. In: Blood. 2006 ; Vol. 108, No. 9. pp. 3161-3167.
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