Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis

B. M. Solomon, K. G. Chaffee, J. Moreira, S. M. Schwager, James R Cerhan, T. G. Call, Neil Elliot Kay, Susan L Slager, T. D. Shanafelt

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

It is unknown whether individuals with monoclonal B-cell lymphocytosis (MBL) are at risk for adverse outcomes associated with chronic lymphocytic leukemia (CLL), such as the risk of non-hematologic cancer. We identified all locally residing individuals diagnosed with high-count MBL at Mayo Clinic between 1999 and 2009 and compared their rates of non-hematologic cancer with that of patients with CLL and two control cohorts: general medicine patients and patients who underwent clinical evaluation with flow cytometry but who had no hematologic malignancy. After excluding individuals with prior cancers, there were 107 high-count MBL cases, 132 CLL cases, 589 clinic controls and 482 flow cytometry controls. With 4.6 years median follow-up, 14 (13%) individuals with high-count MBL, 21 (4%) clinic controls (comparison MBL P

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalLeukemia
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2016

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Lymphocytosis
B-Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Neoplasms
Flow Cytometry
Hematologic Neoplasms
Medicine

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

Cite this

Solomon, B. M., Chaffee, K. G., Moreira, J., Schwager, S. M., Cerhan, J. R., Call, T. G., ... Shanafelt, T. D. (2016). Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis. Leukemia, 30(2), 331-336. https://doi.org/10.1038/leu.2015.235

Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis. / Solomon, B. M.; Chaffee, K. G.; Moreira, J.; Schwager, S. M.; Cerhan, James R; Call, T. G.; Kay, Neil Elliot; Slager, Susan L; Shanafelt, T. D.

In: Leukemia, Vol. 30, No. 2, 01.02.2016, p. 331-336.

Research output: Contribution to journalArticle

Solomon, BM, Chaffee, KG, Moreira, J, Schwager, SM, Cerhan, JR, Call, TG, Kay, NE, Slager, SL & Shanafelt, TD 2016, 'Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis', Leukemia, vol. 30, no. 2, pp. 331-336. https://doi.org/10.1038/leu.2015.235
Solomon, B. M. ; Chaffee, K. G. ; Moreira, J. ; Schwager, S. M. ; Cerhan, James R ; Call, T. G. ; Kay, Neil Elliot ; Slager, Susan L ; Shanafelt, T. D. / Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis. In: Leukemia. 2016 ; Vol. 30, No. 2. pp. 331-336.
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