TY - JOUR
T1 - Risk of Intestinal Cancer in Inflammatory Bowel Disease
T2 - A Population-Based Study From Olmsted County, Minnesota
AU - Jess, Tine
AU - Loftus, Edward V.
AU - Velayos, Fernando S.
AU - Harmsen, W. Scott
AU - Zinsmeister, Alan R.
AU - Smyrk, Thomas C.
AU - Schleck, Cathy D.
AU - Tremaine, William J.
AU - Melton, L. Joseph
AU - Munkholm, Pia
AU - Sandborn, William J.
N1 - Funding Information:
Supported by the Mayo Foundation for Medical Education and Research, AR30582 from the National Institutes of Health, the Astra Zeneca Travel Foundation (visit to Mayo Clinic by T.J.), Augustinus Foundation, Beckett Foundation, Danish Crohn Colitis Foundation, Jacob Madsen and Olga Madsen Foundation, and Sigrid R. Moran Foundation.
PY - 2006/4
Y1 - 2006/4
N2 - Background & Aims: The risk for colorectal cancer in Crohn's disease and ulcerative colitis patients from the United States currently is unknown. We estimated the risk for small-bowel and colorectal cancer in a population-based cohort of 692 inflammatory bowel disease patients from Olmsted County, Minnesota, from 1940 to 2001. Methods: The Rochester Epidemiology Project was used to identify cohort patients with colorectal and small-bowel cancer. The cumulative probability of cancer and standardized incidence ratios (SIR) were estimated using expected rates from Surveillance, Epidemiology, and End Results, white patients from Iowa, from 1973 to 2000, and Olmsted County, from 1980 to 1999. Results: Colorectal cancer was observed in 6 ulcerative colitis patients vs 5.38 expected (SIR, 1.1; 95% confidence interval [CI], 0.4-2.4), but 4 of these occurred among those with extensive colitis or pancolitis (SIR, 2.4; 95% CI, 0.6-6.0). Six Crohn's disease patients (vs 3.2 expected) developed colorectal cancer (SIR, 1.9; 95% CI, 0.7-4.1). Three Crohn's disease patients developed small-bowel cancer vs 0.07 expected (SIR, 40.6; 95% CI, 8.4-118). Conclusions: The risk for colorectal cancer was not increased among ulcerative colitis patients overall, but appeared to be increased among those with extensive colitis. The colorectal cancer risk was increased slightly among Crohn's disease patients, who also had a 40-fold excess risk for small-bowel cancer.
AB - Background & Aims: The risk for colorectal cancer in Crohn's disease and ulcerative colitis patients from the United States currently is unknown. We estimated the risk for small-bowel and colorectal cancer in a population-based cohort of 692 inflammatory bowel disease patients from Olmsted County, Minnesota, from 1940 to 2001. Methods: The Rochester Epidemiology Project was used to identify cohort patients with colorectal and small-bowel cancer. The cumulative probability of cancer and standardized incidence ratios (SIR) were estimated using expected rates from Surveillance, Epidemiology, and End Results, white patients from Iowa, from 1973 to 2000, and Olmsted County, from 1980 to 1999. Results: Colorectal cancer was observed in 6 ulcerative colitis patients vs 5.38 expected (SIR, 1.1; 95% confidence interval [CI], 0.4-2.4), but 4 of these occurred among those with extensive colitis or pancolitis (SIR, 2.4; 95% CI, 0.6-6.0). Six Crohn's disease patients (vs 3.2 expected) developed colorectal cancer (SIR, 1.9; 95% CI, 0.7-4.1). Three Crohn's disease patients developed small-bowel cancer vs 0.07 expected (SIR, 40.6; 95% CI, 8.4-118). Conclusions: The risk for colorectal cancer was not increased among ulcerative colitis patients overall, but appeared to be increased among those with extensive colitis. The colorectal cancer risk was increased slightly among Crohn's disease patients, who also had a 40-fold excess risk for small-bowel cancer.
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U2 - 10.1053/j.gastro.2005.12.037
DO - 10.1053/j.gastro.2005.12.037
M3 - Article
C2 - 16618397
AN - SCOPUS:33645998460
SN - 0016-5085
VL - 130
SP - 1039
EP - 1046
JO - Gastroenterology
JF - Gastroenterology
IS - 4
ER -