Risk of HPV-16/18 Infections and Associated Cervical Abnormalities in Women Seropositive for Naturally Acquired Antibodies: Pooled Analysis Based on Control Arms of Two Large Clinical Trials

Mahboobeh Safaeian, Xavier Castellsagué, Allan Hildesheim, Sholom Wacholder, Mark H. Schiffman, Marie Cécile Bozonnat, Laurence Baril, Dominique Rosillon, A. Chatterjee, S. N. Chow, N. De Carvalho, Del Rosario Raymundo, F. Diaz Mitoma, G. Dubin, S. Garland, M. J. Germar, P. Gonzalez, D. M. Harper, U. Jaisamrarn, A. R. KreimerM. Lehtinen, P. Naud, J. Paavonen, K. Peters, W. Poppe, C. Porras, J. Salmeròn, Mark E. Sherman, S. R. Skinner, F. Struyf, J. Teixeira, W. Tjalma, C. M. Wheeler

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2 Scopus citations

Abstract

Background Studies on the role of antibodies produced after infection with human papillomavirus 18 (HPV-18) and subsequent protection from HPV-18 infection have been conflicting, mainly due to inadequate sample size. Methods We pooled data from the control arms of the Costa Rica Vaccine Trial and the PATRICIA trial. Using Poisson regression we compared the risk of newly detected 1-time HPV-18 infection, HPV-18 1-year persistent infection (12MPI), and HPV-18-associated atypical squamous cells of undetermined significance or greater (ASC-US+) lesions between HPV-18 seropositive and seronegative women. Results High HPV-18 antibodies at enrollment was associated with reduced subsequent HPV-18 detection (P trend = 0.001; relative rate [RR] = 0.69; 95% confidence interval [CI], 0.47-1.01 for the third quartile; RR = 0.63; 95% CI, 0.43-0.94 for the fourth quartile, compared to seronegative). The risk of 12MPI showed a decreasing trend with increasing antibodies (P trend = 0.06; RR = 0.72; 95% CI, 0.29-1.77; RR = 0.42; 95% CI, 0.13-1.32 for the third and fourth quartiles, respectively). Lastly, we observed a significant decreased risk of HPV-18 ASC-US+ with increasing antibody (P trend = 0.01; RR = 0.46; 95% CI, 0.21-0.97 for the fourth quartile). We also observed a significant decreased risk of HPV-16 infection, 12MPI, and ASC-US+ with increasing HPV-16 antibody level. Conclusions High HPV-18 naturally acquired antibodies were associated with partial protection from future HPV-18 infections and associated lesions. Clinical Trials Registration NCT00128661 and NCT001226810.

Original languageEnglish (US)
Pages (from-to)84-94
Number of pages11
JournalJournal of Infectious Diseases
Volume218
Issue number1
DOIs
StatePublished - Jun 5 2018

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Keywords

  • HPV
  • human papillomavirus
  • immunity
  • naturally acquired antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Safaeian, M., Castellsagué, X., Hildesheim, A., Wacholder, S., Schiffman, M. H., Bozonnat, M. C., Baril, L., Rosillon, D., Chatterjee, A., Chow, S. N., De Carvalho, N., Raymundo, D. R., Mitoma, F. D., Dubin, G., Garland, S., Germar, M. J., Gonzalez, P., Harper, D. M., Jaisamrarn, U., ... Wheeler, C. M. (2018). Risk of HPV-16/18 Infections and Associated Cervical Abnormalities in Women Seropositive for Naturally Acquired Antibodies: Pooled Analysis Based on Control Arms of Two Large Clinical Trials. Journal of Infectious Diseases, 218(1), 84-94. https://doi.org/10.1093/infdis/jiy112