Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population

Rok Seon Choung, G. Richard Locke, Cathy D. Schleck, Alan R. Zinsmeister, L. Joseph Melton, Nicholas J. Talley

Research output: Contribution to journalArticle

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Abstract

Objectives: In patients with diabetes mellitus (DM) and upper gastrointestinal symptoms, a diagnosis of diabetic gastroparesis is often considered, but population-based data on the epidemiology of diabetic gastroparesis are lacking. We aimed to estimate the frequency of and risk factors for gastroparesis among community subjects with DM. Methods: In this population-based, historical cohort study, the medical records linkage system of the Rochester Epidemiology Project was used to identify 227 Olmsted County, MN residents with type 1 DM in 1995, a random sample of 360 residents with type 2 DM, and an age-and sex-stratified random sample of 639 nondiabetic residents. Using defined diagnostic criteria, we estimated the subsequent risk of developing gastroparesis in each group through 2006. The risk in DM, compared with frequency-matched community controls, was assessed by Cox proportional hazards modeling. Results: The cumulative proportions developing gastroparesis over a 10-year time period were 5.2% in type 1 DM, 1.0% in type 2 DM, and 0.2% in controls. The age-and gender-adjusted hazard ratios (HRs) for gastroparesis (relative to controls) was 33 (95% confidence interval (CI): 4.0, 274) in type 1 DM and 7.5 (95% CI: 0.8, 68) in type 2 DM. The risk of gastroparesis in type 1 DM was significantly greater than in type 2 DM (HR: 4.4 (1.1, 17)). Heartburn (HR: 6.6 (1.7, 25)) at baseline was associated with diabetic gastroparesis in type 1 DM. Conclusions: Gastroparesis is relatively uncommon in patients with DM, although an increased risk for gastroparesis was observed in type 1 DM.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume107
Issue number1
DOIs
StatePublished - Jan 2012

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Gastroparesis
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Population
Diabetes Mellitus
Medical Record Linkage
Epidemiology
Confidence Intervals
Heartburn
Cohort Studies

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Choung, R. S., Locke, G. R., Schleck, C. D., Zinsmeister, A. R., Melton, L. J., & Talley, N. J. (2012). Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. American Journal of Gastroenterology, 107(1), 82-88. https://doi.org/10.1038/ajg.2011.310

Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. / Choung, Rok Seon; Locke, G. Richard; Schleck, Cathy D.; Zinsmeister, Alan R.; Melton, L. Joseph; Talley, Nicholas J.

In: American Journal of Gastroenterology, Vol. 107, No. 1, 01.2012, p. 82-88.

Research output: Contribution to journalArticle

Choung, RS, Locke, GR, Schleck, CD, Zinsmeister, AR, Melton, LJ & Talley, NJ 2012, 'Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population', American Journal of Gastroenterology, vol. 107, no. 1, pp. 82-88. https://doi.org/10.1038/ajg.2011.310
Choung, Rok Seon ; Locke, G. Richard ; Schleck, Cathy D. ; Zinsmeister, Alan R. ; Melton, L. Joseph ; Talley, Nicholas J. / Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. In: American Journal of Gastroenterology. 2012 ; Vol. 107, No. 1. pp. 82-88.
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AB - Objectives: In patients with diabetes mellitus (DM) and upper gastrointestinal symptoms, a diagnosis of diabetic gastroparesis is often considered, but population-based data on the epidemiology of diabetic gastroparesis are lacking. We aimed to estimate the frequency of and risk factors for gastroparesis among community subjects with DM. Methods: In this population-based, historical cohort study, the medical records linkage system of the Rochester Epidemiology Project was used to identify 227 Olmsted County, MN residents with type 1 DM in 1995, a random sample of 360 residents with type 2 DM, and an age-and sex-stratified random sample of 639 nondiabetic residents. Using defined diagnostic criteria, we estimated the subsequent risk of developing gastroparesis in each group through 2006. The risk in DM, compared with frequency-matched community controls, was assessed by Cox proportional hazards modeling. Results: The cumulative proportions developing gastroparesis over a 10-year time period were 5.2% in type 1 DM, 1.0% in type 2 DM, and 0.2% in controls. The age-and gender-adjusted hazard ratios (HRs) for gastroparesis (relative to controls) was 33 (95% confidence interval (CI): 4.0, 274) in type 1 DM and 7.5 (95% CI: 0.8, 68) in type 2 DM. The risk of gastroparesis in type 1 DM was significantly greater than in type 2 DM (HR: 4.4 (1.1, 17)). Heartburn (HR: 6.6 (1.7, 25)) at baseline was associated with diabetic gastroparesis in type 1 DM. Conclusions: Gastroparesis is relatively uncommon in patients with DM, although an increased risk for gastroparesis was observed in type 1 DM.

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